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1799 – Deep Transcranial Magnet Stimulation Improves Depression And Fatigue In Multiple Sclerosis

Published online by Cambridge University Press:  15 April 2020

G. Gaede ,
M. Tiede ,
I. Lorenz ,
C.F. Pfueller ,
J. Doerr ,
J. Bellmann-Strobl ,
A. Zangen ,
S. Schippling  and
F. Paul
G. Gaede
Affiliation:
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin
M. Tiede
Affiliation:
Institut für Neuroimmunologie und Klinische Multiple Sklerose Forschung, Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
I. Lorenz
Affiliation:
Institut für Neuroimmunologie und Klinische Multiple Sklerose Forschung, Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
C.F. Pfueller
Affiliation:
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin
J. Doerr
Affiliation:
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin
J. Bellmann-Strobl
Affiliation:
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin
A. Zangen
Affiliation:
Department of Life Sciences, Ben-Gurion University, Beer-Sheva, Israel
S. Schippling
Affiliation:
Institut für Neuroimmunologie und Klinische Multiple Sklerose Forschung, Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany
F. Paul
Affiliation:
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Berlin

Abstract

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Introduction

Fatigue and depression are among the most frequent symptoms in multiple sclerosis (MS), affecting up to 90% of patients at onset or during the course of the disease. Repetitive transcranial magnetic stimulation (rTMS) has proven safe and efficacious for treating depression.

Objective

To perform a randomized, sham-controlled pilot study to evaluate effects of deep rTMS on fatigue and depression in patients with multiple sclerosis.

Methods

28 MS-patients underwent 18 sessions of deep rTMS over 6 weeks. 10 patients underwent sham stimulation, 9 patients stimulation of the left prefrontal cortex (PFC) (18 Hz, 120% motor threshold (MT)) and 9 patients of the motor cortex (MC) (5 Hz, 90% MT). Following the treatment, patients were observed for further 6 weeks. Effects on fatigue were evaluated with the Fatigue Severity Scale (FSS) Depression was assessed by Becks Depression Inventory (BDI).

Results

There was no significant change of BDI or FSS in sham group, as well as in PFC group over all time points. However BDI in MC group showed a significant decrease already in early treatment phase (-25.74% ± 24.36%, p = 0.013) and continued decrease over treatment period with maximum in follow up phase (-39.23% ± 21.57, p = 0.001). In FSS, MC group showed a trend to decrease during treatment period and the effect becomes significant in follow up phase (-26,72% ± 16.30%, p = 0.001).

Conclusion

Our data suggests that deep rTMS may have positive influence on depression and fatigue. Intrestingly, comparable effects on both symptoms were observed in MC group but not in PFC or in sham group.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1057
Copyright
Copyright © European Psychiatric Association 2013
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