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1689 – Ginkgo Biloba Extract Egb 761 In Mild Cognitive Impairment With Neuropsychiatric Symptoms: a Randomized Placebo-controlled Trial

Published online by Cambridge University Press:  15 April 2020

U.W. Preuss ,
N. Bachinskaya ,
R. Kaschel ,
J.W. Wong ,
R. Hoerr  and
S.I. Gavrilova
U.W. Preuss
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, Kreiskrankenhaus Prignitz, Perleberg, Germany
N. Bachinskaya
Affiliation:
Institute of Gerontology, Academy of Medical Sciences, Kiev, Ukraine, Germany
R. Kaschel
Affiliation:
Department of Psychology, University of Osnabrueck, Osnabrueck, Germany
J.W. Wong
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, Kreiskrankenhaus Prignitz, Perleberg, Germany
R. Hoerr
Affiliation:
Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany
S.I. Gavrilova
Affiliation:
Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, Russia

Abstract

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Introduction

Ginkgo biloba extract EGb 761® improved neuropsychiatric symptoms (NPS) in patients with dementia in a series of trials.

Objectives/aims

To explore the effects of EGb 761® on NPS in patients with mild cognitive impairment (MCI).

Methods

A randomized, placebo-controlled, double-blind, 24-week, multi-center trial was conducted, including 160 patients with MCI who scored at least 6 on the 12-item Neuropsychiatric Inventory (NPI). Effects on NPS were assessed using the NPI, the state sub-score of the State-Trait Anxiety Inventory (STAI-X1) and the Geriatric Depression Scale (GDS). Further outcome measures were the Trail-Making Test (TMT, Forms A and B) and global ratings of change. Descriptive statistical analyses followed the intention-to-treat principle.

Results

The NPI composite score decreased by 7.0 ± 4.5 (mean, standard deviation) points in the EGb 761®-treated group and by 5.5 ± 5.2 points in the placebo group (p = 0.001). Improvement by at least 4 points was found in 78.8% of patients treated with EGb 761® and in 55.7% of those receiving placebo (p = 0.002). Significant superiority of EGb 761® over placebo was also found for the STAI-X1 score, the informants' global impression of change and both TMT scores. There were statistical trends favoring EGb 761® in the GDS and the patients' global impression of change. Adverse events were reported by 37 patients taking EGb 761® and 36 patients receiving placebo; there were no serious adverse events.

Conclusion

EGb 761® improved NPS and cognitive performance in patients with MCI. The drug was safe and well tolerated.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E965
Copyright
Copyright © European Psychiatric Association 2013
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