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1508 – Association Study Of The Dio2 Gene As a Susceptibility Candidate For Schizophrenia In The Turkish Population; a Case-control Study

Published online by Cambridge University Press:  15 April 2020

A. Colak ,
G. Akan ,
F. Oncu ,
H. Yanbay ,
S. Acar ,
D. Yesilbursa ,
S. Turkcan  and
F. Atalar
A. Colak
Affiliation:
Department of Biomedical Engineering, Bogazici University Department of Growth-Development and Pediatric Endocrinology, Child Health Institute, Istanbul University
G. Akan
Affiliation:
Department of Medical Biology and Genetics, Istanbul Bilim University
F. Oncu
Affiliation:
Psychiatry Clinics, Turkish Ministry of Health Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery
H. Yanbay
Affiliation:
Psychiatry Clinics, Turkish Ministry of Health Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery
S. Acar
Affiliation:
Department of Growth-Development and Pediatric Endocrinology, Child Health Institute, Istanbul University Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey
D. Yesilbursa
Affiliation:
Psychiatry Clinics, Turkish Ministry of Health Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery
S. Turkcan
Affiliation:
Psychiatry Clinics, Turkish Ministry of Health Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery
F. Atalar
Affiliation:
Department of Growth-Development and Pediatric Endocrinology, Child Health Institute, Istanbul University

Abstract

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Introduction

Schizophrenia (SCH) is one of the major and potentially severe mental illness that is characterized by both genetic and clinical heterogeneity. Thyroid hormone plays an important role in the development of the brain and nervous system both in the basic process of neurogenesis and of terminal brain differentiation. Type II deiodinase (DIO2) enzyme which has a critical role on thyroid hormone metabolism to convert pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3). Recently, DIO2 gene variations have been identified in association with mental disorders.

Methods

To investigate the potential genetic contribution of the DIO2 gene to SCH, we studied DIO2 Thr92Ala (rs225014) and ORFa-Gly3Asp (rs12885300) polymorphisms in a Turkish cohort of 290 unrelated SCH patients and 198 healthy controls. All subjects were genotyped by Taqman SNP genotyping assays.

Results

Single marker analysis showed a positive association of SCH and rs225014. Particularly, Thr92Ala genotype frequency was significantly higher in patients with SCH than controls (p=0.045) and in male patients with SCH, both allele and genotype frequencies were significantly higher compared to male controls (p=0.03). Allele and genotype frequencies of ORFa- Gly3Asp polymorphism were no different within the study group.

Conclusion

These data show a potential role of DIO2 as a candidate gene for susceptibility to SCH and provide a strong evidence for a role of the DIO2 Thr92Ala allele and genotype in the etiopathogenesis of SCH with sexual difference.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E814
Copyright
Copyright © European Psychiatric Association 2013
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