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1031 – Risk Of Psychiatric Disorders In Hypospadias - a Nationwide Swedish Cohort Study

Published online by Cambridge University Press:  15 April 2020

A. Butwicka ,
P. Lichtenstein ,
M. Landén ,
A. Nordenström ,
A. Nordenskjöld  and
L. Frisén
A. Butwicka
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (KI), Stockholm, Sweden Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland
P. Lichtenstein
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (KI), Stockholm, Sweden
M. Landén
Affiliation:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (KI), Stockholm, Sweden Institution of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University
A. Nordenström
Affiliation:
Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Department of Molecular Medicine and Surgery
A. Nordenskjöld
Affiliation:
Department of Molecular Medicine and Surgery
L. Frisén
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet (KI), Stockholm, Sweden

Abstract

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Introduction

Even though 0.3-0.8% percent of the male population are born with hypospadias, it is not known if this is associated with an increased risk for psychiatric morbidity later in life.

Aims

The aim of this study was to assess the association between hypospadias and risk of psychiatric disorders in affected individuals.

Methods

The association between hypospadias and psychiatric disorders was examined in a population-based cohort study using Swedish registers. Individuals born in Sweden between 1973 and 2009 were included in the study. Among them, 11,156 patients with hypospadias were identified and matched with 1,098,714 distinct controls by year of birth and county. The following outcomes were evaluated: 1- suicide attempt, 2- psychotic, 3- mood, 4-anxiety, 5- eating, 6- personality disorders, 7- disorders due to psychoactive substance use, 8- ADHD, 9- pervasive developmental disorders, 10- intellectual disabilities, and 11- other childhood emotional disorders.

Results

After adjusting for socio-economic and perinatal factors, malformations and/or genetic syndromes, patients with hypospadias were more likely to be diagnosed with pervasive developmental disorders (OR 1.4; 95% CI 1.1-1.6), intellectual disabilities (OR 1.8; 95% CI 1.6-2.1), ADHD (OR 1.2; 95% CI 1.0-1.4) and other childhood emotional disorders (OR 1.3; 95% CI 1.1-1.4) compared to the controls. No relation between other psychiatric diagnosis and hypospadias was found.

Conclusion

Hypospadias is associated with an increased risk of neurodevelopmental disorders.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E446
Copyright
Copyright © European Psychiatric Association 2013
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