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Signos neurológicos menores y anomalías dermatoglíficas en gemelos con esquizofrenia

Published online by Cambridge University Press:  12 May 2020

B. D. Kelly ,
D. Cotter ,
C. Denihan ,
D. Larkin ,
P. Murphy ,
A. Kinsella ,
D. Walsh ,
J. Waddington ,
C. Larkin  and
E. O’Callaghan
...Show all authors
B. D. Kelly
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
D. Cotter
Affiliation:
Departamento de Psiquiatría, Real Colegio de Médicos en Irlanda, Dublín, Irlanda
C. Denihan
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
D. Larkin
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
P. Murphy
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
A. Kinsella
Affiliation:
Escuela de Matemáticas, Instituto Dublín de Tecnología, Dublín, Irlanda
D. Walsh
Affiliation:
La Junta de Investigación Sanitaria, Dublín, Irlanda
J. Waddington
Affiliation:
Departamento de Farmacología Clínica, Real Colegio de Cirujanos en Irlanda, Dublín, Irlanda
C. Larkin
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
E. O’Callaghan
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda Departamento de Psiquiatría, Colegio Universitario de Dublín, Irlanda
A. Laney
Affiliation:
La Unidadde Investigación Stanley, Departamento de Psiquiatría Adulta, Orden Hospitalaria de San Juan de Dios, Servicio Cluain Mhuire, Co Dublin, Irlanda
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Resumen

La esquizofrenia se asocia con desarrolló neural alterado. Evaluamos los signos neurológicos menores (SNM) y las anomalías dermatoglíficas (recuento total de crestas a-b [RTCAB] y recuento total crestas digitales [RTCD]) en 15 pares de gemelos concordantes y dis-cordantes para esquizofrenia. Las diferencias intrapar en las puntuaciones tanto de SNL como de RTCAB fueron significativamente mayo-res en los pares discordantes comparado con los pares monocigóticos concordantes. No hubo diferencias significativas en las puntuaciones de SNM y RTCAB entre los sujetos con esquizofrenia y los co-gemelos sin la enfermedad. Sin embargo, los gemelos discordantes monocigóticos con esquizofrenia tenían recuentos de crestas a-b (RCAB) mayores en su mano derecha comparado con sus co-gemelos sin la enfermedad. Estos hallazgos indican que un acontecimiento ambiental no identificado que actúa entre las semanas 6 y 15 de la gestación afecta al desarrollo de los gemelos monocigóticos que continúan hasta desarrollar esquizofrenia, pero no tiene un efecto correspondiente en sus co-gemelos que no desarrollan la enfermedad. El efecto de este acontecimiento sobre los perfiles dermatoglíficos parece laterali-zado a la mano derecha en los gemelos afectados.

Keywords

EsquizofreniaEtiologíaSignos neurológicos menoresDermatoglifosGemelos
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 11 , Issue 7 , October 2004 , pp. 423 - 427
Copyright
Copyright © European Psychiatric Association 2004

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