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La respuesta inicial al fármaco activo y al placebo predice la evolución del tratamiento antidepresivo

Published online by Cambridge University Press:  12 May 2020

S. Priebe  and
M. Bröker
S. Priebe
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
M. Bröker
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
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Resumen

En este estudio examinamos si el cambio clínico inicial (CCI) y la respuesta subjetiva inicial (RSI) predicen la evolución de la farmacoterapia antidepresiva, y si el CCI y la RSI reflejan acciones farmacológicas específicas o un efecto placebo como predictores. Cuarenta pacientes con depresión mayor fueron tratados con tres antidepresivos diferentes durante 4 semanas. Se tomaron como criterios de evolución el cambio clínico global y la respuesta subjetiva final. Los pacientes fueron asignados al azar a dos subgrupos en un diseño doble ciego. Inicialmente, un grupo recibió el fármaco activo y el otro, placebo. Después, se dio a todos el fármaco activo. Se encontraron correlaciones significativas entre el CCI y la RSI y al menos uno de los criterios de evolución en la muestra total y en cada subgrupo. Los resultados muestran que el CCI y la RSI pueden ser predictores significativos de la evolución. El valor predictivo del CCI y la RSI no se debe a efectos farmacológicos iniciales, sino a factores de tratamiento no específicos.

Keywords

respuesta inicialantidepresivospredictiónevolucióndepresión
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 6 , September 1997 , pp. 382 - 388
Copyright
Copyright © European Psychiatric Association 1997

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Footnotes

Priebe S, Bröker M. Initial response to active drug and placebo predicts outcome of antidepressant treatment. Eur Psychiatry 1997; 12: 28-33.

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