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Factores que influyen en la investigación de los criterios de valoración de la depresión (FINDER): Diseño del studio y características de la población

Published online by Cambridge University Press:  01 May 2008

Ana García-Cebriár ,
Michael Bauerb ,
Angel L. Montejo ,
Nicolás Dantchev ,
Koen Demyttenaere ,
Paul Gandhi ,
Luigi Grassi ,
Brigitta U. Monz ,
David G.S. Perahia  and
Deborah Quail
...Show all authors
Ana García-Cebriár
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Michael Bauerb
Affiliation:
Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Carl Gnstav Carus, Technische Universität Dresde, Fetscherstrabe 4, D 01307Dresde, Alemania
Angel L. Montejo
Affiliation:
Hospital Universitario de Salamanca, Avda. Comuneros 27, Salamanca37003, España
Nicolás Dantchev
Affiliation:
Unidad de Psiquiatría, Hótel-Dieu, 1 Place du Parvis Notre Dame, 75004París, Francia
Koen Demyttenaere
Affiliation:
Universitair Ziekenhuis Gasthuisberg Herestraat 49, 3000Leuven, Bélgica
Paul Gandhi
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Luigi Grassi
Affiliation:
Universidad de Ferrara, Corso Giovecca 203, 44100Ferrara, Italia
Brigitta U. Monz
Affiliation:
Boehringer Ingelheim GmbH, D 55216Ingelheim, Alemania
David G.S. Perahia
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido Hospital Gordon, Bloomburg Street, Londres SWIV 2RH, Reino Unido
Deborah Quail
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Andre Tylee
Affiliation:
Sección de Salud Mental de Atención Primaria, Departamento de Investigación de la Población y Senecios Sociales, Instituto de Psiquiatría, Parque De Crespigny, Denmark Hill, Londres SE5 8AF, Reino Unido
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Resumen

Los factores que influyen en los resultados de depresión en la práctica clínica, sobre todo, la calidad de vida relacionada con la salud (CVRS), son relativamente desconocidos. El estudio de los Factores que Influyen en la Investigación de los Criterios de Valoración de la Depresión (FINDER) es un estudio europeo prospectivo de observación diseñado para estimar la CVRS de adultos con un episodio depresivo diagnosticado en la clínica inicialmente, y 3 y 6 meses después del comienzo del tratamiento antidepresivo. Describimos aquí el diseño del estudio y las características iniciales de los pacientes.

La CVRS se evaluó con el Cuestionario de Salud de 36 apartados (SF-36) y en el Cuestionario Europeo de Calidad de Vida de 5 Dimensiones (EQ-5D). También se determinaron las Puntuaciones de los pacientes en la Escala de Depresión, y Ansiedad Hospitalaria (HADS) y en la Escala Analógica Visual (EAV). Los resultados (n=3.468) demostraron que el resumen del componente mental del custionario SF-36 (media 22,2) estaba más de dos DE por debajo de la norma de la población general (media 50) y una DE por debajo de la norma de la depresión clínica (media 34,8); el resumen del componente físico (media 46,1) fue similar a la población general (media 50) y a la norma de depresión clínica (media 45). Las puntuaciones medias de EQ-5D eran tambien inferiores que la norma de la población general. Las puntuaciones medias de depresión y ansiedad de HADS eran 12,3 y 13, respectivamente. El 56% de los pacientes describió una puntuación total del dolor en la EAV de, al menos, 30 mm y el 70% de estos pacientes no tenía ninguna explicación física de su dolor.

Deben realizarse más investigaciones sobre los factores asociados con la CVRS en pacientes con depresión después de la iniciación del tratamiento.

Keywords

DepresiónEuropaEstudio de observaciónCalidad de vida
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 4 , May 2008 , pp. 187 - 196
Copyright
Copyright © European Psychiatric Association 2008

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