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Evaluación de potenciales evocados endógenos en la depresión: una revision

Published online by Cambridge University Press:  12 May 2020

J. L. Nandrino
Affiliation:
Unidad de Investigación en Psicofisiología Cognitiva, CNRS URA 654-LENA, Hospital de la Salpêtrière, París, Francia;
F. El Massioui
Affiliation:
Unidad de Investigación en Psicofisiología Cognitiva, CNRS URA 654-LENA, Hospital de la Salpêtrière, París, Francia;
J. Everett
Affiliation:
Escuela de Psicología, Universidad Laval, Quebec, Canadá
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Resumen

Durante los 15 últimos años, los investigadores han mostrado un interés cada vez mayor por utilizar los potenciales evocados cognitivos (ERPs) para estudiar la depresión. En general, estos estudios se dividen en cuatro clases: 1) los ERPs como medio de detectar la depresión; 2) los ERPs como herramienta para distinguir subtipos de depresión; 3) los ERPs como medida de la efectividad farmacológica; 4) los ERPs como indicadores de operaciones cognitivas defectuosas en sujetos deprimidos. Los resultados de estos enfoques heterogéneos son a menudo inconsistentes y decepcionantes. Aunque algunos componentes del ERP muestran con frecuencia mayores latencias y menores amplitudes, estos cambios parecen reflejar principalmente una variedad de trastornos no específicos que afectan a un amplio conjunto de funciones cognitivas, más que un déficit preciso y consistente de una función particular. Estos resultados decepcionantes parecen ser atribuibles a problemas metodológicos (poblaciones de pacientes heterogéneos, uso desproporcionado del paradigma de “estímulo atípico” [odd-ball]) y no ponen necesariamente en tela de juicio el valor de estudiar los ERP. Además, recientes avances en la metodología de los ERP han abierto nuevas perspectivas para su uso en psicopatología.

Type
Artículo original
Copyright
Copyright © European Psychiatric Association 1997

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Footnotes

Nandrino JL, El Massioui F, Everett J. Endogenous evoked potentials assessment in depression: a review. Eur Psychiatry 1996; 11: 357-368

References

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