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Distribución estacional de los nacimientos en pacientes con la enfermedad de Alzheimer y pacientes depresivos mayores

Published online by Cambridge University Press:  12 May 2020

U. Ptok ,
A. Papassotiropoulos ,
W. Maier  and
R. Heun
U. Ptok
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
A. Papassotiropoulos
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
W. Maier
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
R. Heun
Affiliation:
Departamento de Psiquiatría, Universidad de Bonn, Sigmund-Freud-St. 2553105, Bonn, Alemania
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Resumen

Los nacimientos en invierno se han asociado con un riesgo más elevado de enfermedad de Alzheimer (EA) y otros trastornos psiquiátricos. En la presente investigación, se examinó esta asociación putativa en una muestra de pacientes gerontopsiquiátricos. Un análisis de las tasas de nacimiento trimestrales de 83 pacientes con EA, 78 pacientes depresivos mayores con comienzo temprano del trastorno depresivo y 74 pacientes con comienzo tardío, 48 pacientes con EA y depresión a la vez (pacientes comórbidos) y 107 sujetos de control sanos no reveló una distribución estacional particular para ninguno de los grupos diagnósticos. En los pacientes con EA y comórbidos, controlar el genotipo de la ApoE no cambió este hallazgo. El análisis de regresión matemática reveló los hallazgos esperados de que la mayor edad y la presencia del alelo ApoE4 se asociaban con un riesgo más elevado de demencia. La menor edad y el género femenino se identificaron como factores de riesgo para trastorno depresivo. Haber nacido en invierno (en los tres primeros meses del aflo) no se asociaba con ninguno de los subgrupos diagnóstics. Concluimos que, en nuestra muestra, no se encontró que una distribución estacional de los nacimientos aumentara el riesgo para EA o depresión geriátrica.

Keywords

enfermedad de Alzheimergenotipo de la ApoEdepresión en la persona mayorestación de nacimiento
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 8 , Issue 6 , September 2001 , pp. 378 - 383
Copyright
Copyright © European Psychiatric Association 2001

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