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Cambio en la intensidad del dolor con venlafaxina administrada de forma abierta en pacientes con sintomatología depresiva: estudio de observación en la atención primaria

Published online by Cambridge University Press:  12 May 2020

Stefan Begré ,
Martin Traber ,
Martin Gerber  and
Roland von Känel
Stefan Begré
Affiliation:
Departamento de Medicina Interna, División de Medicina Psicosomática, Hospital Universitario/Inselspital, CH-3010Berna, Suiza
Martin Traber
Affiliation:
Laboratorios Wyeth AG, Grafenauweg 10, CH-6301Zug, Suiza
Martin Gerber
Affiliation:
GEM Clinical Research Consulting M. Gerber, Gewerbestrasse 6, CH-6314Unterägeri/ZG, Suiza
Roland von Känel
Affiliation:
Departamento de Medicina Interna, División de Medicina Psicosomática, Hospital Universitario/Inselspital, CH-3010Berna, Suiza
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Resumen

Objetivo

Venlafaxina ha demostrado ser eficaz en el tratamiento de la depresión y del dolor. Carecemos de datos sobre el resultado de los pacientes con dolor crónico y síntomas depresivos tratados con venlafaxina en el marco de la atención primaria. Este estudio de observación intentó definir la eficacia de venlafaxina y su prescripción por los médicos de atención primaria y psiquiatras suizos en pacientes con dolor crónico y sintomatología depresiva.

Sujetos y métodos

Estudiamos a 505 pacientes con síntomas depresivos que sufrían dolor crónico en un estudio prospectivo naturalista de observación con venlafaxina en la atención primaria suiza. Estos pacientes fueron tratados con venlafaxina por 122 médicos (psiquiatras, médicos generalistas e internistas).

Resultados

Por término medio, los pacientes recibieron con 143 ± 75 mg (0-450 mg) de venlafaxina al día durante tres meses. Venlafaxina demostró ser eficaz tanto en el tratamiento de los síntomas depresivos como del dolor crónico.

Discusión

Aunque no se observaron efectos secundarios en la mayor parte de los pacientes, posiblemente no se consiguió una respuesta satisfactoria de la depresión por administrar dosis bajas de venlafaxina. Nuestros resultados reflejan la complejidad del tratamiento de dolor crónico en pacientes con síntomas depresivos en la atención primaria.

Conclusión

Son necesarios nuevos estudios aleatorizados que determinen la dosis apropiada de venlafaxina para el tratamiento de la depresión y del dolor coexistente.

Keywords

DolorDepresión unipolarAntidepresivoPsiquiatría en EuropaSuizaAtención primariaVenlafaxinaAtención clínica
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 6 , September 2008 , pp. 298 - 307
Copyright
Copyright © European Psychiatric Association 2008

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