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Asociación de los genes del receptor D2 de dopamina y del alcohol deshidrogenasa 2 con alcohólicos polinesios

Published online by Cambridge University Press:  12 May 2020

S. Amadéo ,
E.P. Noble ,
M. L. Fourcade-Amadéo ,
C. Tetaría ,
M. F. Brugiroux ,
L. Nicolás ,
X. Deparis ,
A. Elbaz ,
X. Zhang  and
T. Ritchíe
...Show all authors
S. Amadéo
Affiliation:
Servicio de Psiquiatría Adulta, Hospital Vaiami, Papeete Tahiti, Polinesia francesa Laboratorio de Genética Molecular de la Neurotransmisión y de los Procesos Neurodegenerativos, CNRS, Edificio CERVI, Hospital dela Piedad Salpétriére, París, Francia
E.P. Noble
Affiliation:
Instituto Neuropsiquiátrico e Instituto de Investigación del Cerebro de la UCLA, Los AngelesCA, EEUU.
M. L. Fourcade-Amadéo
Affiliation:
CHT de Mamao y Centro de Transfusión de Sangre, Papeete Tahiti
C. Tetaría
Affiliation:
CHT de Mamao y Centro de Transfusión de Sangre, Papeete Tahiti
M. F. Brugiroux
Affiliation:
Servicio de Alcohología y Toxicomanía, Papeete Tahiti
L. Nicolás
Affiliation:
Instituto Territorial de Investigaciones Médicas Louis Malardé, Papeete Tahiti, Polinesia francesa
X. Deparis
Affiliation:
Instituto Territorial de Investigaciones Médicas Louis Malardé, Papeete Tahiti, Polinesia francesa
A. Elbaz
Affiliation:
INSERM, Pointe á Pitre, Guadalupe.
X. Zhang
Affiliation:
Instituto Neuropsiquiátrico e Instituto de Investigación del Cerebro de la UCLA, Los AngelesCA, EEUU.
T. Ritchíe
Affiliation:
Instituto Neuropsiquiátrico e Instituto de Investigación del Cerebro de la UCLA, Los AngelesCA, EEUU.
P.V. Martin
Affiliation:
Instituto Territorial de Investigaciones Médicas Louis Malardé, Papeete Tahiti, Polinesia francesa
J. Mallet
Affiliation:
Laboratorio de Genética Molecular de la Neurotransmisión y de los Procesos Neurodegenerativos, CNRS, Edificio CERVI, Hospital dela Piedad Salpétriére, París, Francia
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Resumen

Se determinaron los alelos de los genes del receptor D2 de dopamina (DRD2) y del alcohol deshidrogenasa 2 (ADH2) en 69 pacientes alcohólicos de la Polinesia francesa y 57 controles empa- rejados en cuanto a su origen racial. Se estudiaron tres grupos raciales: polinesios puros (PP), polinesios mezclados con ascendencia caucasiana (PACauc) y polinesios mezclados con ascendencia china (PACh). En estos grupos, las frecuencias del alelo Al del DRD2 en los alcohólicos en comparación con sus controles fueron: PP: 0,26 frente a 0,32 (P = 0,69); PACauc: 0,44 frente a 0,35 (P = 0,46); PACh: 0,40 frente a 0,39 (P = 0,88). Las frecuencias del alelo 1 de la ADH2 en alcohólicos en comparación con sus grupos de control fueron: PP: 0,56 frente a 0,62 (P = 0,66); PACauc: 0,75 frente a 0,56 (P = 0,09); PACh: 0,78 frente a 0,32 (P = 0,009). En el grupo de PACauc, la combinación de los geno- tipos Al del DRD2 y los homocigotos 1 de la ADH2 estaba fuertemente asociada con el alcoholismo (P = 0,0027). Este estudio preliminar muestra la importancia de comprobar la ascendencia racial en los estudios de asociación de genética molecular. Además, indica que en la susceptibilidad al desarrollo del alcoholismo está implicada una combinación de genes.

Keywords

ADHALDHDRD2alcoholismoestudios de asociaciónpolinesios
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 7 , Issue 7 , October 2000 , pp. 448 - 454
Copyright
Copyright © European Psychiatric Association 2000

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