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Asociación alélica entre repeticiones de dinucleótidos en los loci de la monoamino oxidasa y la esquizofrenia

Published online by Cambridge University Press:  12 May 2020

J. Wei  and
G. P. Hemmings
J. Wei
Affiliation:
Instituto de Psiquiatría, Asociación de Esquizofrenia de Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd LL57 2AGReino Unido
G. P. Hemmings
Affiliation:
Instituto de Psiquiatría, Asociación de Esquizofrenia de Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd LL57 2AGReino Unido
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Resumen

Se determinaron dos microsatélites ligados al X, las repeticiones (AC)n en el locus A de la monoamino oxidasa (MAO) y (TG)n en el locus B de la MAO, utilizando un procedimiento basado en la reacción en cadena de la polimerasa (PCR) en 89 familias nucleares que constaban de madre, padre y descendiente mujer afectada con esquizofrenia o madre y descendiente varón afectado. Se aplicó un enfoque de riesgo relativo de haplotipo basado en el haplotipo (HHRR) para detectar la asociación alélica de estos dos microsatélites con la esquizofrenia. En las familias de los pacientes varones, se encontró una diferencia significativa en la distribución de frecuencias entre las repeticiones (TG)n transmitidas y no transmitidas (χ2 = 15,13, gl = 6, P = 0,019), y la prueba exacta de Fisher mostró que la frecuencia alélica de la (TG)24 transmitida era significativamente más alta que la de la (TG)24 no transmitida (P de Fisher = 0,003). Sin embargo, no se encontraron diferencias significativas en la distribución de frecuencias entre las repeticiones (TG)n transmitidas por la madre o por el padre y las no transmitidas en las familias de las pacientes mujeres. No se encontraron diferencias significativas en la distribución de frecuencias entre las repeticiones (AC)n transmitidas y no transmitidas en las familias de pacientes varones o de pacientes mujeres. El presente estudio indica que el gen MAO-B puede estar asociado con la esquizofrenia y el mecanismo genético subyacente de la esquizofrenia puede diferir entre los esquizofrénicos varones y mujeres individuales.

Keywords

monoamino oxidasagenmicrosatélitereacción en cadena de la polimerasa (PCR)esquizofrenia
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 6 , Issue 4 , May 1999 , pp. 238 - 242
Copyright
Copyright © European Psychiatric Association 1999

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