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Alteraciones de las concentraciones de factor neurotrófico derivado de la línea de células gliales (GDNF) en el cerebro de pacientes con trastorno depresivo: Estudio comparativo post mortem.

Published online by Cambridge University Press:  12 May 2020

Tanja M. Michel ,
Sophia Frangou ,
Sibylle Camara ,
Dorothea Thiemeyer ,
Julia Jecel ,
Thomas Tatschner ,
Robert Zoechling  and
Edna Griinblatt
Tanja M. Michel
Affiliation:
Universidad RWTH Aachen, Departamento de Psiquiatría y Psicoterapia, Pauwelsstrasse 30, 52074Aachen, Alemania Sección de Neurobiología de la Psicosis, PO 66, Centro de Investigación Biomédica NIHR e Instituto de Psiquiatría, King 's College Londres, De Crespigny Park, SE5 SAF, Londres, RU Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Würzburg Füchsleinstrasse 15, 97080Würburg, Germany
Sophia Frangou
Affiliation:
Sección de Neurobiología de la Psicosis, PO 66, Centro de Investigación Biomédica NIHR e Instituto de Psiquiatría, King 's College Londres, De Crespigny Park, SE5 SAF, Londres, RU
Sibylle Camara
Affiliation:
Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Würzburg Füchsleinstrasse 15, 97080Würburg, Germany
Dorothea Thiemeyer
Affiliation:
Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Würzburg Füchsleinstrasse 15, 97080Würburg, Germany
Julia Jecel
Affiliation:
Instituto Medicina Forense, Universidad Würburg, Alemania
Thomas Tatschner
Affiliation:
Departamento de Psiquiatría, Hospital Mostviertel Amstetten-Mauer, Austria
Robert Zoechling
Affiliation:
Departamento de Neurología, Hospital Danubio, Viena, Austria
Edna Griinblatt
Affiliation:
Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Würzburg Füchsleinstrasse 15, 97080Würburg, Germany
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Resumen

Introducción

Hay cada vez más evidencias que indican que el factor neurotrófico derivado de la línea de células gliales (GDNF) está implicado en la etiopatología de los trastornos del ánimo. El GDNF es un factor neurotrófico de la familia de los factores transformadores del crecimiento que desempeña algún papel en el desarrollo de las células y en la función del sistema límbico. Éste es el primer estudio que ha examinado la concentración de GDNF en diferentes regiones cerebrales de pacientes con trastorno depresivo (TD).

Material y métodos

Usamos una técnica sandwich-ELISA para determinar la concentración de GDNF y el ensayo de Lowry para calcular las concentraciones de proteínas totales en tejido cerebral p o st mortem en 7 pacientes con trastorno depresivo recurrente y en 14 individuos sin ningún diagnóstico neurológico o psiquiátrico. Incluimos regiones corticales y áreas límbicas (hipocampo, corteza entorrinal), ganglios basales (putamen, núcleo caudal), tálamo y circunvolución cingulada.

Resultados

Encontramos un aumento significativo de la concentración de GDNF en la corteza parietal de los pacientes con TD comparados con el grupo de control. En otras regiones, la tendencia al aumento de la concentración de GDNF no indicó ninguna diferencia estadísticamente significativa.

Discusión

Este estudio de prueba de concepto confirma resulados anteriores que indicaban que había una alteración del GDNF en pacientes con trastorno depresivo. Sin embargo, es la primera vez que se ha encontrado un aumento significativo de GDNF en un área cortical cerebral en pacientes con TD.

Keywords

Trastorno psiquiatricoTrastornos afectivosNeurocienciaMixtoAntidepresivoGDNF
Type
Original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 8 , November 2008 , pp. 398 - 406
Copyright
Copyright © European Psychiatric Association 2008

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