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Adaptación social y trastorno de ansiedad generalizada: un estudio a largo plazo controlado con placebo de la venlafaxina de liberación prolongada

Published online by Cambridge University Press:  12 May 2020

Patrice Boyer ,
Vincent Mahé  and
David Hackett
Patrice Boyer
Affiliation:
CNRS UMR 7593, Hôpital de la Pitié-Salpétriére, 47, Boulevard de L’Hôpital, 75651París, Francia
Vincent Mahé
Affiliation:
Servicio de Psiquiatría, Hospital General de Meaux, Francia
David Hackett
Affiliation:
Wyeth Research, París, Francia
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Resumen

El objetivo de este análisis era evaluar la eficacia a corto (8 semanas) y largo plazo (24 semanas) de tres dosis fijas de venlafaxina de liberación prolongada (LP) y placebo en la adaptación social de los pacientes contrastorno de ansiedad generalizada (TAG). Analizamos los datos de 544 pacientes ambulatorios que participant en un estudio multicéntrico doble ciego de grupos paralelos controlado con placebo de 24 semanas realizado en 55 centros en cinco países. Todos los pacientes cumplían los criterios del DSM-IV para TAG y se asignaron aleatoriamente para recibir 37,5, 75 y 150 mg de venlafaxina LP o placebo emparejado administrado oralmente una vez al día. La adaptación social se midió utilizando la Escala de Adaptación Social-Autoinforme, que explora la adaptación social en las áreas laboral, social y de ocio, familia extensa, relación primaria (matrimonial), parental y unidad familiar. En la línea de base, los pacientes con TAG tenían un nivel alto de disfunción social. La venlafaxina LP mostró una mejoría relacionada con la dosis en el deterioro social durante el tratamiento a corto plazo y en el mantenimiento de esta mejoria a largo plazo. En el subgrupo con deterioro social mas importante, las tasas de remisión con el placebo en la HAM-A fueron bajas, y la magnitud de la diferencia venlafaxina-placebo en la puntuación total media de la HAM-A fue alta, alcanzando más de 7 puntos. Los beneficios del tratamiento de venlafaxina LP del TAG se extienden más alia de la mejoría de los síntomas de ansiedad, a una mejoría significativa en el deterioro del funcionamiento que se asocia con la enfer medad.

Keywords

Trastorno de ansiedad generalizadaDeterioro socialVenlafaxina
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 11 , Issue 8 , November 2004 , pp. 500 - 507
Copyright
Copyright © European Psychiatric Association 2000

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