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Activación frontal disminuida en esquizofrénicos durante la estimulación con la prueba de ejecución continua: un estudio de imágenes de resonancia magnética funcionales

Published online by Cambridge University Press:  12 May 2020

H. P. Volz ,
C. Gaser ,
F. Häger ,
R. Rzanny ,
J. Pönisch ,
H. J. Mentzel ,
W. A. Kaiser  and
H. Sauer
H. P. Volz
Affiliation:
Departamento de Psiquiatría.
C. Gaser
Affiliation:
Departamento de Psiquiatría.
F. Häger
Affiliation:
Departamento de Psiquiatría.
R. Rzanny
Affiliation:
Instituto de Diagnóstico y Radiología Intervencional UDIR), Universidad de Friedrich-Schiller, Philosophenweg 3, D-07740, Jena, Alemania
H. J. Mentzel
Affiliation:
Instituto de Diagnóstico y Radiología Intervencional UDIR), Universidad de Friedrich-Schiller, Philosophenweg 3, D-07740, Jena, Alemania
W. A. Kaiser
Affiliation:
Instituto de Diagnóstico y Radiología Intervencional UDIR), Universidad de Friedrich-Schiller, Philosophenweg 3, D-07740, Jena, Alemania
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Resumen

La prueba de ejecución continua (CPT) se ha convertido en un componente esencial de la investigación neuropsicológica de la esquizofrenia. Además, un número considerable de estudios de imágenes cerebrales, en la mayor parte investigaciones de PET, ha empleado la CPT como estímulo cognitivo y ha establecido una hipofrontalidad relativa en los esquizofrénicos en comparación con los controles. El propósito de la presente investigación era clarificar si esta hipofrontalidad descrita antes se podía verificar también utilizando imágenes de resonancia magnética funcionales (fMRI). Se incluyó a 20 voluntarios sanos y 14 esquizofrénicos con medicación neuroléptica estable. La toma de imágenes se realizó utilizando la CPT, versión T doble, y un escáner clínico de MRI de 1,5 T con una técnica de rodaja única y una secuencia de gradiente de eco potenciado en T¡*. Los esquizofrénicos mostraron una activación disminuida en el córtex prefrontal medial derecho, el cingulado derecho y el tálamo izquierdo en comparación con los controles. Estos resultados obtenidos por fMRI se analizan con relación a los resultados publicados utilizando PET.

Keywords

imágenes de resonancia magnética funcionalesesquizofreniaprueba de ejecución continuaatenciónhipofrontalidad
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 6 , Issue 8 , November 1999 , pp. 509 - 518
Copyright
Copyright © European Psychiatric Association 1999

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