Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-24T20:57:01.578Z Has data issue: false hasContentIssue false
  • English
  • Français

La respuesta inicial al fármaco activo y al placebo predice la evolución del tratamiento antidepresivo

Published online by Cambridge University Press:  12 May 2020

S. Priebe  and
M. Bröker
S. Priebe
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
M. Bröker
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
Get access

Resumen

En este estudio examinamos si el cambio clínico inicial (CCI) y la respuesta subjetiva inicial (RSI) predicen la evolución de la farmacoterapia antidepresiva, y si el CCI y la RSI reflejan acciones farmacológicas específicas o un efecto placebo como predictores. Cuarenta pacientes con depresión mayor fueron tratados con tres antidepresivos diferentes durante 4 semanas. Se tomaron como criterios de evolución el cambio clínico global y la respuesta subjetiva final. Los pacientes fueron asignados al azar a dos subgrupos en un diseño doble ciego. Inicialmente, un grupo recibió el fármaco activo y el otro, placebo. Después, se dio a todos el fármaco activo. Se encontraron correlaciones significativas entre el CCI y la RSI y al menos uno de los criterios de evolución en la muestra total y en cada subgrupo. Los resultados muestran que el CCI y la RSI pueden ser predictores significativos de la evolución. El valor predictivo del CCI y la RSI no se debe a efectos farmacológicos iniciales, sino a factores de tratamiento no específicos.

Keywords

respuesta inicialantidepresivospredictiónevolucióndepresión
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 6 , September 1997 , pp. 382 - 388
Copyright
Copyright © European Psychiatric Association 1997

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Priebe S, Bröker M. Initial response to active drug and placebo predicts outcome of antidepressant treatment. Eur Psychiatry 1997; 12: 28-33.

References

Bibliografia

American Psychiatric Association. Diagnostic and Statistical Manual o f Mental Disorders, 3rd edn Revised, DSM-III-R. Washington, DC: American Psychiatric Association, 1987.Google Scholar
Bartko, G, Herczeg, I, Bekesy, M. Predicting outcome of neuroleptic treatment on the basis of subjective response and early clinical improvement. J Clin Psychiatry 1987; 48: 363-5.Google ScholarPubMed
Bielski, RJ, Friedel, RO. Prediction of tricyclic antidepressant response: A critical review. Arch Gen Psychiatry 1976; 33: 1479-89.CrossRefGoogle ScholarPubMed
Brody, H. Placebos and the Philosophy o f Medicine. Chicago: The University of Chicago Press, 1980.Google Scholar
Bröker, M, Rohricht, F, Priebe, S.Initial assessment of hospital treatment by patients with paranoid schizophrenia: A predictor of outcome. Psychiatr Res 1995; 58: 77-81.CrossRefGoogle ScholarPubMed
Coryell, W, Coppen, A, Zeigler, VE, Biggs, JT. Early improvement as a predictor of response to amitriptiline and nortriptyline: a comparison of 2 patient samples. Psychol Med 1982; 12: 135-9.CrossRefGoogle Scholar
Fink, EB, Braden, W, Qualls, CB. Predicting pharmacotherapy outcome by subjective response. J Clin Psychiatry 1982; 43: 272-5.Google ScholarPubMed
Goodwin, FK. Predictors of antidepresant response. Bull Meninger Clin 1993; 57: 146-60.Google Scholar
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.CrossRefGoogle ScholarPubMed
Joyce, CRB. Non-specific aspects of treatment from the point of view of a clinical pharmacologist. In: Shepherd, M, Sartorius, N, eds. Non-Specific Aspects o f Treatment. Toronto: Huber, 1989: 57-94.Google Scholar
Joyce, PR, Paykel, ES. Predictors of drug response in depression. Arch Gen Psychiatry 1989; 46: 89-99.CrossRefGoogle ScholarPubMed
Katz, MM, Koslow, SH, Maas, JW et al. The timing, specificity and clinical prediction of tricyclic drug effects in depression. Psychol Med 1987; 17: 297-309.CrossRefGoogle ScholarPubMed
Klerman, GL, Cole, JO. Clinical pharmacology of imipramine and related antidepressant compounds. Pharmacol Rev 1965; 17: 101-41.Google ScholarPubMed
Kocsis, JH. New issues in the prediction of antidepressant response. Psychopharmacol Bull 1990; 16: 49-53.Google Scholar
May, PRA, Goldberg, SC.Prediction of schizophrenic patient's response to pharmacotherapy. In: Lipton, MA, DiMascio, A, Killam, KF, eds. Psychopharmacology: A Generation o f Progress. New York: Raven: 1978: 1139-53.Google Scholar
May, PRA, Van Putten, T, Yale, C et al. Predicting individual responses to drug treatment in schizophrenia: A test dose model. J Nerv Ment Dis 1976; 162: 177-83.CrossRefGoogle ScholarPubMed
May, PRA, Van Putten, T, Yale, C.Predicting outcome of antipsychotic drug treatment from early response. Am J Psychiatry 1980; 137: 1088-9.Google ScholarPubMed
May, PRA, Van Putten, T, Jenden, DJ, Yale, C, Dixon, WJ, Goldstein, MJ. Prognosis in schizophrenia: Individual differences in psychological response to a test dose of antipsychotic drug and their relationship to blood and saliva levels and treatment outcome. Compr Psychiatry 1981; 22: 147-52.CrossRefGoogle ScholarPubMed
Morris, JB, Beck, AT. The efficacy of antidepressant drugs. A review of research (1958-1972). Arch Gen Psychiatry 1974; 30: 667-74.CrossRefGoogle ScholarPubMed
Nagayama, H, Nagano, K, Ikezaki, A, Tashiro, T. Prediction of efficacy of antidepresant by 1-week test therapy in depression. J Ajfect Dis 1991; 23: 213-6.CrossRefGoogle Scholar
Nedopil, N, Ruther, E. Initial improvement as predictor of outcome of neuroleptic treatment. Pharmacopsychiat 1981; 14: 205-7.CrossRefGoogle ScholarPubMed
Nedopil, N, Pflieger, R, Ruther, E. The prediction of acute response, remission and general outcome of neuroleptic treatment in acute schizophrenic patients. Pharmacopsychiat 1983; 16: 201-5.CrossRefGoogle ScholarPubMed
Priebe, S. Early subjective reactions predicting the outcome of hospital treatment in depressive patients. Acta Psychiatr Scand 1987; 76: 134-138.CrossRefGoogle ScholarPubMed
Priebe, S.Die Bedeutung der Patientenmeinung. Initiale Bewertung und Verlauf psychiatrischer Therapie. Gottingen: Hogrefe, 1992.Google Scholar
Priebe, S, Gruyters, T. Patient's and caregivers’ initial assessments of day hospital treatment and course of symptoms. Compr Psychiatry 1994; 35: 234-8.CrossRefGoogle Scholar
Priebe, S, Gruyters, T. The importance of the first three days: Predictors of treatment outcome in depressed inpatients. Br J Clin Psychol 1995; 34: 229-36.CrossRefGoogle Scholar
Rickels, K.Non-specific factor in drug therapy of neurotic patients. In: Rickels, K, ed Non-Specific Factors in Drug Therapy. Springfield: Thomas, 1968: 3-26.Google Scholar
Rothschild, R, Quitkin, FM. Review of the use of pattern analysis to differentiate true and drug and placebo responses. Psychother Psychosom 1992; 58: 170-7.CrossRefGoogle ScholarPubMed
Singh, MM. Dysphoric response to neuroleptic treatment in schizophrenia and its prognostic significance. Dis Nerv Syst 1976; 37: 191-6.Google ScholarPubMed
Singh, MM, Kay, SR. Dysphoric response to neuroleptic treatment in schizophrenia: Its relationship to autonomic arousal and prognosis. Biol Psychiatry 1979; 14: 277-94.Google ScholarPubMed
Singh, MM, Smith, JM. Kinetics and dynamics of response to haloperidol in acute schizophrenia - a longitudinal study of the therapeutic process. Compr Psyciatry 1973; 14: 393-414.CrossRefGoogle ScholarPubMed
Van Putten, T, May, PRA. Subjective response as a predictor of outcome in pharmacotherapy. Arch Gen Psyciatry 1978; 35: 477-80.CrossRefGoogle ScholarPubMed
Van Putten, T, May, PRA, Jenden, DJ, Cho, AK, Jale, C.Plasma and saliva levels of chlorpromazine and subjective response. Am J Psychiatry 1980a; 137: 1241-2.Google Scholar
Van Putten, T, May, PRA, Marder, SR.Subjective responses to thiotixine and chlorpromazine. Psychopharmacol Bull 1980b; 16: 36-8.Google Scholar
Van Putten, T, May, PRA, Marder, SR, Wittman, LA. Subjective response to antipsychotic drugs. Arch Gen Psychiatry 1981; 38: 187-90.CrossRefGoogle ScholarPubMed
Woggon, B, Baumann, U. Multimethodological approach in psychiatric predictor research. Pharmacopsychiat 1983; 16: 175-78.CrossRefGoogle ScholarPubMed
Woggon, B.Unsolved problems in the pharmacotherapy of depression. In: Casey, DE, Christensen, AV, eds. Psychopharmacology: Current Trends. Psychopharmacology Series 5. Berlin: Springer, 1988: 159-65.CrossRefGoogle Scholar