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La leucocitopenia en pacientes tratados con clozapina puede estar inducida por otros fármacos: una serie clinica

Published online by Cambridge University Press:  12 May 2020

Mary Jo Imbarlina ,
Sonali Sarkar ,
Shashi Marwah ,
Haranath Parepally ,
Phillip R. Johnston ,
Jaspreet S. Brar  and
K. N. Roy Chengappa
Mary Jo Imbarlina
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview
Sonali Sarkar
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Shashi Marwah
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview
Haranath Parepally
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Phillip R. Johnston
Affiliation:
instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
Jaspreet S. Brar
Affiliation:
instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
K. N. Roy Chengappa
Affiliation:
Centro de Estudios Especiales en el Hospital Estatal de Mayview instituto y Clínica Psiquiátricos del Oeste, Centro Médico de la Universidad de Pittsburgh, Pittsburgh, PA 15213-2593, EE. UU.
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Resumen

La combinación de clozapina y otros medicamentos potencialmente leucocitopénicos puede plantear un riesgo mayor de neutrocitopenia. Sin embargo, la neutrocitopenia puede no deberse siempre a la clozapina. Al añadir medicamentos potencialmente leucocitopénicos, los profesionales clínicos deben buscar posibles alternativas, en especial porque la clozapina es un fármaco que se utiliza a menudo como último recurso en el tratamiento de la esquizofrenia resistente.

Keywords

LeucocitopeniaClozapinaAgranulocitosisHematopoyesisEsquizofrenia
Type
Comunicación breve
Information
European Psychiatry (Ed. Española) , Volume 12 , Issue 3 , April 2005 , pp. 181 - 184
Copyright
Copyright © European Psychiatric Association 2005

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Footnotes

Imbarlina MJ, Sarkar S, Marwah S, Parepally H, Johnston PR, Brar JS, Chengappa KNR. Leukopenia in clozapine treated patients may be induced by other drugs: a case series. Eur Psychiatry 2004;19:506-509.

References

Bibliografía

[1]Alvir, JMLieberman, JASafferman, AZSchwimmer, JLSchaaf, JA. Clozapine- induced agranalocytosis: incidence and risk factors in the United States. N Engl J Med 1993; 329: 162-7.CrossRefGoogle ScholarPubMed
[2]Brenner, LO. Agranulocytosis and ranitidine (Letter). Ann Intern Med 1986; 104: 896-7.CrossRefGoogle Scholar
[3]Capellari, GGaio, ACavallaro, ACardaioli, CSimioni, L, La Valle R, et al. Use of colony stimulating factors for the treatment of druginduced agranlocytosis. Br J Haematol 1993; 84: 183-4.CrossRefGoogle Scholar
[4]Devinsky, OHonigfeld, GPatin, J. Clozapine related seizures. Neurology 1991; 41: 369-71.CrossRefGoogle ScholarPubMed
[5]Facciola, GAvenoso, AScordo, MGAldo, GVentimiglia, APerucca, E, et al. Small effects of valprotic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. Ther Drug Monit 1999; 21: 341-7.CrossRefGoogle ScholarPubMed
[6]Finley, PWarner, D. Potential impact of valproic acid therapy on clozapine disposition. Biol Psychiatry 1994; 36: 487-8.CrossRefGoogle ScholarPubMed
[7]Kando, JCTohen, MCastillo, JCentorrino, F. Concurrent use of clozapine and valproate in affective and psychotic disorders. J Psychiatry 1994; 55: 255-7.Google ScholarPubMed
[8]Kane, JHonigfeld, GSinger, JMeltzer, H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988; 45: 789-96.Google ScholarPubMed
[9]Lane, GPSpeed, B. Agranulocytosis after ranitidine administration. Med JAust 1989; 150: 595-6.Google ScholarPubMed
[10]Madeb, RHirschmann, SKurs, RTurkie, AModai, I. Combined clozapine and valproic acid treatment induced agranulocytosis. Eur Psychiatry 2002; 17: 238-9.CrossRefGoogle ScholarPubMed
[11]Patton, WN. Use of colony stimulating factors in the treatment of drug-induced agranulocytosis. Br J Haematol 1993,84:184-5.Google Scholar
[12]Patton, WPHolyoake, TLYates, JMBoughton, BJFranklin, IM. Accelerated recovery from drug-induced agranulocytosis following G-CSF therapy. Br J Haematol 1992; 80: 564-5.CrossRefGoogle ScholarPubMed
[13]Peacock, LGerlach, J. Clozapine treatment in Denmark: concomitant psychotropic medication and hematologic monitoring in a System with liberal usage practices. J Clin Psychiatry 1994; 55: 44-9.Google Scholar
[14]Senechal, ALandry, PDeschamps, RLessard, M. Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs. Encephale 2002; 28: 567-9.Google Scholar
[15]Shields, LIFiles, JADoli, DCGreensburg, BR. Ranitidine and agranulocytosis (Letter). Ann Intern Med 1986; 104: 128.CrossRefGoogle Scholar
[16]Watts, RGEmanuel, PDSucherman, KSHoward, TH. Valproic acid induced cytopenia: evidence for a dose-related suppression of hematopoiesis. J Pediatr 1990; 117: 495-9.CrossRefGoogle Scholar
[17]Wilson, WH. Do anticonvulsants hinder clozapine treatment? Biol Psychiatry 1995; 37: 132-3.CrossRefGoogle ScholarPubMed