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Datos para un aumento en los receptores 5-HT2A funcionales de las plaquetas en pacientes deprimidos utilizando el nuevo ligando [l25I]-DOI

Published online by Cambridge University Press:  12 May 2020

F. Serres ,
J.M. Azorin ,
M. Valli  and
R. Jeanningros
F. Serres
Affiliation:
Inserm U 501, UER de Medicine Nord, BdP. Dramard, 13916Marseilles cedex 20, Francia
J.M. Azorin
Affiliation:
Inserm U 501, UER de Medicine Nord, BdP. Dramard, 13916Marseilles cedex 20, Francia
M. Valli
Affiliation:
Inserm U 501, UER de Medicine Nord, BdP. Dramard, 13916Marseilles cedex 20, Francia
R. Jeanningros
Affiliation:
Inserm U 501, UER de Medicine Nord, BdP. Dramard, 13916Marseilles cedex 20, Francia
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Resumen

Se han implicado anomalías en el sistema serotonérgico en la patofisiología de los trastornos depresivos. Las plaquetas humanas poseen receptores de serotonina-2A (5-HT2A), e investigaciones anteriores que han utilizado LSD o ketanserina como ligandos han indicado que su número se incrementa en los pacientes deprimidos. Comparado con otros ligandos utilizados antes en los estudios de plaquetas, el DOI es muy selectivo para el receptor 5-HT2A y se fija a su estado de alta afinidad, marcando por tanto sólo los receptores que están asociados biológicamente a la proteína G. Determinamos la densidad (Bmax) y la afinidad (Kd) de receptores 5-HT2A marcados por [l25I]-DOI en las plaquetas de 21 pacientes no tratados con depresión mayor y 21 voluntarios sanos. Se encontró que la densidad de los sitios de fijación de 5-HT2A se incrementaba en las plaquetas de las pacientes deprimidas en comparación con los controles. No se observaron cambios en la Kd. No encontramos ninguna relación entre los parámetros de fijación y la gravedad del episodio depresivo o las tendencias suicidas de los pacientes. Nuestros resultados muestran que el número de receptores 5-HT2A acoplados de las plaquetas se incrementa en los pacientes deprimidos, lo que indica que la función del receptor 5-HT2A de las plaquetas aumenta en la depresión.

Keywords

receptores 5-HT2AdepresiónDOIplaquetasserotonina
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 7 , Issue 5 , June 2000 , pp. 294 - 303
Copyright
Copyright © European Psychiatric Association 2000

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