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Uneventful total intravenous anaesthesia with ketamine for schizophrenic surgical patients

Published online by Cambridge University Press:  16 August 2006

H. Ishihara ,
H. Kudo ,
T. Murakawa ,
A. Kudo ,
S. Takahashi  and
A. Matsuki
H. Ishihara
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
H. Kudo
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
T. Murakawa
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
A. Kudo
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
S. Takahashi
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
A. Matsuki
Affiliation:
Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki-Shi, 036 Japan
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Abstract

Ketamine has been considered to be contraindicated for schizophrenic patients because it may induce psychological emergence reactions and psychiatric deterioration. Total intravenous anaesthesia (TIVA) with ketamine combined with droperidol and fentanyl (DFK) has been used in 14 schizophrenic patients undergoing various surgical procedures. Two patients died post-operatively of concomitant severe disease rather than from schizophrenia related pathophysiology or anaesthetic complication. One patient showed transient mild anxiety in the early post-operative period soon relieved by the patient's routine medication. However, no patient developed exacerbations of psychosis or psychological emergence reactions during the first post-operative month. The cardiovascular state during and after DFK remained stable in all cases. It is concluded that ketamine when combined with droperidol and fentanyl is a satisfactory anaesthetic for patients with schizophrenia.

Keywords

schizophreniaanaesthetic agentsketaminetotal intravenous anaesthesia
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 1 , January 1997 , pp. 47 - 51
Copyright
1997 European Society of Anaesthesiology

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