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Recovery of intentional dynamic balance function after intravenous sedation with midazolam in young and elderly subjects

Published online by Cambridge University Press:  01 March 2006

T. Fujisawa ,
S. Takuma ,
H. Koseki ,
K. Kimura  and
K. Fukushima
T. Fujisawa
Affiliation:
Hokkaido University, Graduate School of Dental Medicine, Department of Dental Anesthesiology, Sapporo, Japan
S. Takuma
Affiliation:
Hokkaido University, Graduate School of Dental Medicine, Department of Dental Anesthesiology, Sapporo, Japan
H. Koseki
Affiliation:
Hokkaido University, Graduate School of Dental Medicine, Department of Dental Anesthesiology, Sapporo, Japan
K. Kimura
Affiliation:
Hokkaido University, Graduate School of Dental Medicine, Department of Dental Anesthesiology, Sapporo, Japan
K. Fukushima
Affiliation:
Hokkaido University, Graduate School of Dental Medicine, Department of Dental Anesthesiology, Sapporo, Japan
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Abstract

Summary

Background and objective: Computerized dynamic posturography using an intentional postural-sway task can be used to assess body-leaning ability and postural-control ability to prevent falls. Falls are the leading cause of morbidity and mortality for the elderly. The purpose of the present study was to evaluate the recovery of intentional dynamic balance function after intravenous sedation with midazolam in elderly subjects in comparison with that in young subjects. Methods: Midazolam was administered in small, divided doses over 4–5 min until the Wilson sedation score reached three in 20 young and 18 elderly male volunteers. The dynamic limits of the stability test, in which subjects leaned their body intentionally as indicated by a cursor moving on a computer screen, was determined before (baseline) and 50, 70, 90, 110, and 130 min after administration of midazolam. Results: The changes from baseline values of path sway and movement time 50 min after the administration of midazolam in elderly subjects (106.8 ± 101.0%, 4.6 ± 3.0 s; mean ± SD) were significantly greater than those (32.9 ± 87.2%, 1.9 ± 2.8 s) in young subjects (P = 0.024, P = 0.008), respectively. Conclusions: The elderly show slower recovery of the intentional dynamic balance function than do young adults after intravenous sedation with midazolam.

Keywords

CONSCIOUS SEDATION, MIDAZOLAM, AGED, RECOVERY OF FUNCTION, MUSCULOSKELETAL EQUILIBRIUM, intentional dynamic balance
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 5 , May 2006 , pp. 422 - 425
Copyright
2006 European Society of Anaesthesiology

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