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A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures

Published online by Cambridge University Press:  11 July 2005

V. A. Peduto ,
S. Baroncini ,
S. Montanini ,
R. Proietti ,
L. Rosignoli ,
R. Tufano  and
A. Casati
V. A. Peduto
Affiliation:
University of Perugia, Department of Medicina Clinica e Sperimentale, Policlinico Monteluce, Perugia, Italy
S. Baroncini
Affiliation:
Policlinico S. Orsola Malpighi, Department of Anaesthesiology, Bologna, Italy
S. Montanini
Affiliation:
Policlinico Universitario, Department of Anaesthesiology, Messina, Italy
R. Proietti
Affiliation:
Università Cattolica del Sacro Cuore, Department of Anaesthesiology, Rome, Italy
L. Rosignoli
Affiliation:
CTO, Department of Anaesthesiology, Rome, Italy
R. Tufano
Affiliation:
Ospedale Policlinico II, Department of Anaesthesiology, Università di Napoli, Naples, Italy
A. Casati
Affiliation:
Vita-Salute University of Milano, Department of Anaesthesiology, IRCCS H San Raffaele, Milan, Italy
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Extract

Summary

Background and objective: This prospective, randomized, observer-blinded study compared onset time and duration of epidural anaesthesia produced by with levobupivacaine and ropivacaine for lower limb surgery.

Methods: ASA I–III adult patients undergoing elective lower limb procedures were randomized to receive epidural levobupivacaine 0.5% 15 mL (n = 30) or epidural ropivacaine 0.75% 15 mL (n = 35). A blinded observer evaluated onset time and regression of motor and sensory block, and intraoperative needs for fentanyl supplementation (0.1 mg intravenously).

Results: With levobupivacaine, onset time was 29 ± 24 min, with ropivacaine it was 25 ± 22 min (P = 0.41). Complete resolution of motor block required 105 ± 63 min with levobupivacaine and 95 ± 48 min with ropivacaine (P = 0.86). The time for regression of sensory block to T12 was 185 ± 77 min with levobupivacaine and 201 ± 75 min with ropivacaine (P = 0.46). Analgesic supplementation was required in one patient receiving levobupivacaine (3.5%) and in two patients receiving ropivacaine (5.7%) (P = 0.99).

Conclusions: In adults undergoing lower limb surgery, levobupivacaine 0.5% 15 mL produces an epidural block with the same clinical profile as ropivacaine 0.75% 15 mL.

Keywords

ANAESTHESIA, CONDUCTION, anaesthesia epiduralANAESTHETICS, LOCAL, levobupivacaine, ropivacaine
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 12 , December 2003 , pp. 979 - 983
Copyright
© 2003 European Society of Anaesthesiology

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