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Propofol does not affect platelet aggregation

Published online by Cambridge University Press:  04 August 2006

H. Türkan ,
A. H. Süer ,
C. Beyan  and
A. Yalçin
H. Türkan
Affiliation:
Department of Anaesthesiology, Gülhane Military Medical Academy 06010 Etlik, Ankara, Turkey
A. H. Süer
Affiliation:
Department of Anaesthesiology, Gülhane Military Medical Academy 06010 Etlik, Ankara, Turkey
C. Beyan
Affiliation:
Department of Haematology, Gülhane Military Medical Academy 06010 Etlik, Ankara, Turkey
A. Yalçin
Affiliation:
Department of Haematology, Gülhane Military Medical Academy 06010 Etlik, Ankara, Turkey
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Abstract

Abnormalities of platelet haemostasis pose increased risk to patients undergoing anaesthesia and surgery. We have investigated the effect of propofol on platelet aggregation in 12 patients undergoing upper and lower abdominal surgery. Propofol 2.5 mg kg−1 was administered via a cannula in the antecubital vein. Venous blood samples were obtained before induction and 10 min after administration of propofol. Platelet aggregation measurements were made for adenosine diphosphate (ADP), collagen and adrenaline. The results show that propofol does not affect platelet aggregation in the concentrations used.

Keywords

bloodplatelet aggregationanaesthetics intravenouspropofol
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 4 , April 1996 , pp. 408 - 409
Copyright
1996 European Society of Anaesthesiology

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