Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-02T22:09:23.754Z Has data issue: false hasContentIssue false
  • English
  • Français

Partial liquid ventilation: effects of closed breathing systems, heat-and-moisture-exchangers and sodalime absorbers on perfluorocarbon evaporation

Published online by Cambridge University Press:  23 December 2005

C. T. Wilms ,
P. Schober ,
R. Kalb  and
S. A. Loer
C. T. Wilms
Affiliation:
Heinrich-Heine-University Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany
P. Schober
Affiliation:
Heinrich-Heine-University Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany
R. Kalb
Affiliation:
Heinrich-Heine-University Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany
S. A. Loer
Affiliation:
Heinrich-Heine-University Düsseldorf, Department of Anaesthesiology, Düsseldorf, Germany
Get access

Extract

Summary

Background and objectives: During partial liquid ventilation perfluorocarbons are instilled into the airways from where they subsequently evaporate via the bronchial system. This process is influenced by multiple factors, such as the vapour pressure of the perfluorocarbons, the instilled volume, intrapulmonary perfluorocarbon distribution, postural positioning and ventilatory settings. In our study we compared the effects of open and closed breathing systems, a heat-and-moisture-exchanger and a sodalime absorber on perfluorocarbon evaporation during partial liquid ventilation. Methods: Isolated rat lungs were suspended from a force transducer. After intratracheal perfluorocarbon instillation (10 mL kg−1) the lungs were either ventilated with an open breathing system (n = 6), a closed breathing system (n = 6), an open breathing system with an integrated heat-and-moisture-exchanger (n = 6), an open breathing system with an integrated sodalime absorber (n = 6), or a closed breathing system with an integrated heat-and-moisture-exchanger and a sodalime absorber (n = 6). Evaporative perfluorocarbon elimination was determined gravimetrically. Results: When compared to the elimination half-life in an open breathing system (1.2 ± 0.07 h), elimination half-life was longer with a closed system (6.4 ± 0.9 h, P < 0.01), a sodalime absorber (5.0 ± 0.6 h, P < 0.01) or a heat-and-moisture-exchanger (4.5 ± 0.8 h, P < 0.01). The combination of all three methods (7.1 ± 0.8 h) showed no significant additional effects (P > 0.05) when compared to a closed system. Conclusions: Evaporative perfluorocarbon loss can be reduced effectively with closed breathing systems, followed by the use of sodalime absorbers and heat-and-moisture-exchangers.

Keywords

LIQUID VENTILATION, partialFLUOROCARBONS, evaporationRATS
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 1 , January 2006 , pp. 31 - 35
Copyright
© 2006 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Loer SA, Kindgen-Milles D, Tarnow J. Partial liquid ventilation: effects of liquid volume and ventilatory settings on perfluorocarbon evaporation. Eur Respir J 2002; 20: 1499–1504.Google Scholar
Loer SA, Schwarte LA, Pakulla MA, Picker O, Scheeren TW. Partial liquid ventilation: effects of positive end-expiratory pressure on perfluorocarbon evaporation from the lungs of anesthetized dogs. Intens Care Med 2003; 29: 467–470.Google Scholar
Jeng MJ, Trevisanuto D, Weis CM et al. Role of ventilation strategy on perfluorochemical evaporation from the lungs. J Appl Physiol 2001; 90: 1365–1372.Google Scholar
Shaffer TH, Foust III R, Wolfson MR, Miller Jr TF. Analysis of perfluorochemical elimination from the respiratory system. J Appl Physiol 1997; 83: 1033–1104.Google Scholar
Trevisanuto D, Jeng MJ, Weis CM, Fox WW, Wolfson MR, Shaffer TH. Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs. Biol Neonate 2003; 84: 53–58.Google Scholar
Weis CM, Fox WW, Philips CM, Wolfson MR, Shaffer TH. Perfluorochemical elimination from the lungs: effect of initial dose. Pediatr Pulmonol 2000; 30: 324–329.Google Scholar
Reickert C, Pranikoff T, Overbeck M et al. The pulmonary and systemic distribution and elimination of perflubron from adult patients treated with partial liquid ventilation. Chest 2001; 119: 515–522.Google Scholar
Schrader B, Westenskow D, Kofoed S et al. A closed rebreathing system for dose maintenance during partial liquid ventilation. Biomed Instrum Technol 1999; 33: 373–382.Google Scholar
Nugent LJ, Mazzoni MC, Flaim SF, Hoffman JK, Sekins KM. Dose maintenance for Partial Liquid Ventilation: passive heat-and-moisture exchangers. Biomed Instrum Technol 1999; 33: 365–372.Google Scholar