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Ondansetron, droperidol and their combination for the prevention of post-operative vomiting in children

Published online by Cambridge University Press:  16 August 2006

A. Klockgether-Radke ,
S. Neumann ,
P. Neumann ,
U. Braun  and
H. Mühlendyck
A. Klockgether-Radke
Affiliation:
Department of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August-University of Göttingen, Göttingen, Germany
S. Neumann
Affiliation:
Department of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August-University of Göttingen, Göttingen, Germany
P. Neumann
Affiliation:
Department of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August-University of Göttingen, Göttingen, Germany
U. Braun
Affiliation:
Department of Anaesthesiology, Emergency Medicine and Intensive Care, Georg-August-University of Göttingen, Göttingen, Germany
H. Mühlendyck
Affiliation:
Department of Strabology and Neuroophthalmology, Georg-August-University of Göttingen, Göttingen, Germany
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Abstract

In this study the antiemetic effects of droperidol, ondansetron and their combination were evaluated in 160 ASA Grade I and II children undergoing surgery for strabismus, who were randomly assigned to one of four groups: Group D received droperidol 75 μg kg−1, group O ondansetron 0.1 mg kg−1, group D + O received both droperidol 75 μg kg−1 and ondansetron 0.1 mg kg−1, and group N NaCl as placebo. Emesis within the first 24 h occurred in 95.0% of the children with placebo medication, compared with 32.5% (D), 40.0% (O) and 45.0% (D + O) in the groups with antiemetic prophylaxis. The differences between group N and all other groups were significant (P < 0.001). However, there were no statistically significant differences between the groups D, O and D + O. It is concluded that droperidol (75 μg kg−1) and ondansetron (0.1 mg kg−1) both significantly reduce PONV in children undergoing surgery for strabismus. Neither ondansetron, nor the combination D+O were superior to droperidol alone.

Keywords

vomitingstrabismus surgerydroperidolondansetron
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 4 , July 1997 , pp. 362 - 367
Copyright
1997 European Society of Anaesthesiology

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