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Neostigmine added to lidocaine axillary plexus block for postoperative analgesia

Published online by Cambridge University Press:  16 August 2006

A. C. Van Elstraete ,
F. Pastureau ,
T. Lebrun  and
H. Mehdaoui
A. C. Van Elstraete
Affiliation:
Department of Anaesthesiology, Saint-Paul Medical Center, University Hospital, Fort-de-France, Martinique, France
F. Pastureau
Affiliation:
Department of Anaesthesiology, Saint-Paul Medical Center, University Hospital, Fort-de-France, Martinique, France
T. Lebrun
Affiliation:
Department of Anaesthesiology, Saint-Paul Medical Center, University Hospital, Fort-de-France, Martinique, France
H. Mehdaoui
Affiliation:
Intensive Care Unit, University Hospital, Fort-de-France, Martinique, France
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Abstract

Background and objective We have assessed the analgesic efficacy and side-effects of neostigmine when added to lidocaine for axillary brachial plexus block, in a prospective, randomized, double-blind, placebo-controlled study.

Methods We studied 34 ASA I or II patients undergoing elective ambulatory carpal tunnel release. Axillary brachial plexus block was performed using a peripheral nerve stimulator to locate the median nerve. All patients were administered 1.5% lidocaine 450 mg and epinephrine 5 μg mL−1. Patients were allocated randomly to one of two groups. Neostigmine 500|ig was added in group N, and saline 1 mL in group S.

Results The duration of analgesia did not significantly differ between groups [mean (SD)]: 812.5 (456.9) for group S vs. 746.7 (474.1) min for group N (P >0.05). The need for supplementary analgesia did not significantly differ between groups: 4.4 (1.5) extra doses for group S vs. 3.8 (2.2) extra doses for group N (P>0.05). Visual analogue pain scores and occurrence of side-effects did not significantly differ between groups.

Conclusion Neostigmine does not seem to be of clinical value for peripheral nerve blocks.

Keywords

analgesiapostoperativeanaesthetic techniquesbrachial plexus blocksympathetic nervous systempharmacologyneostigmine
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue 4 , April 2001 , pp. 257 - 260
Copyright
2001 European Society of Anaesthesiology

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