Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-27T21:08:10.077Z Has data issue: false hasContentIssue false
  • English
  • Français

Local vs. systemic immune and haemostatic response to hip arthroplasty

Published online by Cambridge University Press:  16 August 2006

M. Kristiansson ,
M. Soop ,
K. G. Sundqvist ,
A. Soop ,
A. M. Suontaka  and
M. Blombäck
M. Kristiansson
Affiliation:
Department of Anaesthesiology and Intensive Care, Karolinska Institute, Huddinge University Hospital, Sweden
M. Soop
Affiliation:
Department of Anaesthesiology and Intensive Care, Karolinska Institute, Huddinge University Hospital, Sweden
K. G. Sundqvist
Affiliation:
Department of Clinical Immunology, Karolinska Institute, Huddinge University Hospital, Sweden Department of Clinical Immunology, University Hospital of Umeå, Sweden
A. Soop
Affiliation:
Department of Anaesthesiology and Intensive Care, Karolinska Institute, Huddinge University Hospital, Sweden
A. M. Suontaka
Affiliation:
Department of Clinical Chemistry and Blood Coagulation, Karolinska Institute, Karolinska University Hospital
M. Blombäck
Affiliation:
Department of Clinical Chemistry and Blood Coagulation, Karolinska Institute, Karolinska University Hospital
Get access

Abstract

Local and systemic immune and haemostatic responses were studied in 10 patients, aged 57–78 years, undergoing elective hip arthroplasty. Cytokines, soluble cytokine receptors, interleukin-1 receptor antagonist, soluble adhesion molecules, antithrombin, fibrin, soluble and fibrin d-dimer were analysed in wound drainage blood and in blood taken from the systemic circulation for up to 24 h post-operatively. Wound drainage blood concentrations of cytokines, interleukin-1 receptor antagonist and soluble cytokine receptors were increased compared with those in the systemic circulation except for the soluble interleukin-6 receptor. In wound drainage blood, soluble tumour necrosis factor receptors (P<0.05), interleukin-1 receptor antagonist (P<0.05) and interleukin-6 (P<0.05–<0.01) increased during the study period. In blood from the systemic circulation interleukin-6 increased (P<0.05) while the soluble interleukin-6 receptor decreased (P<0.05) compared with pre-operative values. Concentrations of soluble adhesion molecules did not change. Wound drainage blood showed marked hypercoagulation. After hip arthroplasty pro-inflammatory cytokines and their inhibitors were mainly confined to the local trauma site. A predominance for inhibitors was noted.

Keywords

haemostatic responselocalsystemiccytokinesfibrinolysiship arthroplasty
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 15 , Issue 3 , May 1998 , pp. 260 - 270
Copyright
1998 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)