Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-27T10:35:39.081Z Has data issue: false hasContentIssue false
  • English
  • Français

Ketamine-induced changes in metabolic and endocrine parameters of normal and 2-kidney 1-clip rats

Published online by Cambridge University Press:  13 October 2005

T. Saranteas ,
N. Zotos ,
C. Chantzi ,
C. Mourouzis ,
G. Rallis ,
S. Anagnostopoulou  and
C. Tesseromatis
T. Saranteas
Affiliation:
University of Athens, Medical School, Department of Pharmacology, Athens, Greece ‘Gennimatas’, General Hospital of Athens, Department of Anaesthesiology, Athens, Greece
N. Zotos
Affiliation:
University of Ioannina, General Hospital of Ioannina, Microbiology and Biochemistry Unit, Ioannina, Greece
C. Chantzi
Affiliation:
‘Gennimatas’, General Hospital of Athens, Department of Anaesthesiology, Athens, Greece
C. Mourouzis
Affiliation:
University of Athens, Medical School, Department of Pharmacology, Athens, Greece
G. Rallis
Affiliation:
University of Athens, Medical School, Department of Pharmacology, Athens, Greece
S. Anagnostopoulou
Affiliation:
University of Athens, Medical School, Department of Anatomy, Athens, Greece
C. Tesseromatis
Affiliation:
University of Athens, Medical School, Department of Pharmacology, Athens, Greece
Get access

Extract

Summary

Background and objective: The aim of this study was to investigate the effect of ketamine on the endocrine and lipid metabolic status of the renal-banded animals. Methods: Forty male rats were randomly divided into four groups. Group A served as control, Group B animals received ketamine intraperitoneally at a dose of 100 mg kg−1, Group C was submitted to 2-kidney 1-clip experimental hypertension and Group D received ketamine as above, as well as being submitted to renal artery clipping. Atrial natriuretic peptide, angiotensin II and free fatty acid concentrations were measured in serum. In addition, adipose tissue lipoprotein lipase activity and angiotensin II content were determined, while the left ventricular weight relative to body weight was used as a cardiac hypertrophy index. Results: In renal-banded rats (Groups C and D) serum atrial natriuretic peptide, free fatty acid and angiotensin II concentrations as well as ventricular weight were increased, while adipose tissue lipoprotein lipase activity was lower than in control animals (Groups A and B). Ketamine administration did not influence angiotensin II concentrations either in normal (Group B) or banded rats (Group D). Ketamine increased serum atrial natriuretic peptide and free fatty acid concentrations only in normal animals (Group B). It had no influence on adipose tissue lipoprotein lipase activity either in normal (Group B) or banded animals (Group D). Adipose angiotensin II content did not differ between the four groups. Conclusion: Ketamine increased the atrial natriuretic peptide and free fatty acid concentration in normal rats. In 2-kidney 1-clip animals, ketamine did not elicit an additional response of serum atrial natriuretic peptide or free fatty acids levels. Its contribution to these factors was not significant.

Keywords

ATRIAL NATRIURETIC FACTORANAESTHETICS, INTRAVENOUS, ketamineLIPIDSFATTY ACIDS NONESTERIFIEDANGIOTENSINSRENIN–ANGIOTENSIN SYSTEM
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 11 , November 2005 , pp. 875 - 878
Copyright
© 2005 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Vallottori MB. The renin–angiotensin system. Trend Pharmacol Sci 1987; 8: 69–74.Google Scholar
Kagiyama S, Varela A, Phillips I, Galli M. Antisense inhibition of brain renin–angiotensin system decreased blood pressure in chronic 2-kidney, 1 clip hypertensive rats. Hypertension 2001; 37 (Part 2): 371–375.Google Scholar
Cogan MG. Atrial natriuretic peptide. Kidney Int 1990; 37: 1148–1160.Google Scholar
Bartel S, Hoch B, Vetter D, Krause EG. Expression of human angiotensinogen–renin in rat. Effects on transcription and heart function. Hypertension 2002; 39: 219–223.Google Scholar
Disuza SE, Davis M, Baxter CF. Autocrine and paracrine action of antidiuretic peptide in the heart. Pharmacol Ther 2004; 101: 113–129.Google Scholar
Schorr U, Blasche K, Turan S, Distler A, Sharma AM. Relationship between angiotensinogen, leptin and blood pressure in young normotensive men. J Hypertens 1998; 16: 1475–1480.Google Scholar
Moro C, Crampes F, Sengenes C et al. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans. FASEB J 2004; 18: 908–910.Google Scholar
Leiter LA, Lewanczuk RZ. Of the renin–angiotensin system and reactive oxygen species: type 2 diabetes and angiotensin II inhibition. Am J Hypertens 2005; 18: 121–128.Google Scholar
Galitzky J, Sengenes C, Thalamas C et al. The lipid-mobilizing effect of arterial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men. J Lipid Res 2001; 42: 536–544.Google Scholar
White PF, Way WL, Trevor AJ. Ketamine – its pharmacology and therapeutic uses. Anesthesiology 1982; 56: 119–136.Google Scholar
Stoelting KR. Nonbarbiturate induction drugs. In: Stoelting KR, ed. Pharmacology and Physiology in Anesthetic Practice. Philadelphia: Lippincott Williams & Wilkins, 1999: 148–154.
Flecknell PA. Anaesthesia. In: Tuffery AA, ed. Laboratory Animals – An Introduction for Experiments. London: John Wiley and Sons, 1995: 325.
Nakao S, Nagata A, Miyamoto E, Masuzawa T, Murayama T, Shingu K. Inhibitory effects of propofol on ketamine-induced C-fos expression in the rat posterior cigalate and retroselenical corticles is mediated by GABAA receptor activation. Acta Anaesthesiol Scand 2003; 47: 284–290.Google Scholar
Saranteas T, Lolis E, Mourouzis C, Potamianou A, Tesseromatis C. Effect of losartan on insulin plasma concentrations and LPL-activity in adipose tissue of hypertensive rats. Horm Metab Res 2003; 35: 164–168.Google Scholar
Rule DC, Andersen MK, Balley JW, Swain L, Ficek SJ, Thomas P. Frozen storage of ovine and rats tissues adversely affects lipoprotein lipase activity. J Nutr Biochem 1996; 7: 577–581.Google Scholar
Nagase M, Anto K, Katsuyki A et al. Role of natriuretic peptide receptor type C in Dahl-Salt-Sensitve hypertensive rats. Hypertension 1997; 30: 177–185.Google Scholar
Pantos C, Davos C, Carageorgiou H, Varonos D, Cokkinos D. Ischaemic preconditioning protects against myocardial dysfunction caused by ischaemia in isolated hypertrophied hearts. Basic Res Cardiol 1996; 91: 444–449.Google Scholar
Saavedra JM. Brain and pituitary angiotensin. Endocr Rev 1992; 13: 329–380.Google Scholar
Matsubara H. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998; 83: 1182–1191.Google Scholar
Levin ER, Gender DG, Samson WK. Natriuretic peptides. N Engl J Med 1998; 339: 321–328.Google Scholar
Focaccio A, Volpe M, Ambrasio G, Lembo G, Pannain S, Rubattu S. Angiotensin II directly stimulates release of atrial natriuretic factor in isolated rabbit hearts. Circulation 1993; 87: 192–198.Google Scholar
Carlsson PO. The renin–angiotensin system in the endocrine pancreas. JOP 2001; 2: 26–32.Google Scholar
Jeandel L, Okamura H, Belles-Isles M et al. Immunocytochemical localization, binding, and effects of atrial natriuretic peptide in rats adipocytes. Mol Cell Endocrinol 1988; 62: 69–78.Google Scholar
Saranteas T, Zotos N, Lolis E et al. Mechanisms of ketamine action on lipid metabolism in rats. Eur J Anaesth 2005; 22: 222–226.Google Scholar