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Is intraperitoneal levobupivacaine with epinephrine useful for analgesia following laparoscopic cholecystectomy? A randomized controlled trial

Published online by Cambridge University Press:  23 December 2004

A. Ng ,
A. Swami ,
G. Smith ,
G. Robertson  and
D. M. Lloyd
A. Ng
Affiliation:
Leicester Royal Infirmary, University Department of Anaesthesia, Critical Care and Pain Management, Leicester, UK
A. Swami
Affiliation:
Leicester Royal Infirmary, University Department of Anaesthesia, Critical Care and Pain Management, Leicester, UK
G. Smith
Affiliation:
Leicester Royal Infirmary, University Department of Anaesthesia, Critical Care and Pain Management, Leicester, UK
G. Robertson
Affiliation:
Leicester Royal Infirmary, Department of Surgery, Leicester, UK
D. M. Lloyd
Affiliation:
Leicester Royal Infirmary, Department of Surgery, Leicester, UK
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Abstract

Summary

Background and objective: A randomized controlled trial of patients undergoing laparoscopic cholecystectomy. To evaluate whether the instillation of levobupivacaine, with epinephrine, intraperitoneally, reduces morphine consumption; further, to consider the degree of abdominal and shoulder pain in the presence of local anaesthetic at the site of surgical incision.

Methods: Patients received a standardized procedure and were allocated randomly to receive either (a) 2.5 mg mL−1 levobupivacaine 30 mL, with epinephrine 5 μg mL−1, or (b) normal saline 30 mL, with epinephrine 5 μg mL−1, to the bed of the gall bladder and above the liver, immediately before wound closure.

Results: Median (interquartile range) total abdominal pain during inspiration in the levobupivacaine group was significantly (P = 0.041) lower (71 (21–129) mm) than that in the placebo group (123 (71–179) mm). However, there was no significant difference between the two groups with respect to total abdominal pain at rest, right shoulder pain or the consumption of rescue morphine and rescue dihydrocodeine. There were no differences between the two groups with respect to the administration of cyclizine, total nausea and total sedation scores. In addition, the number of episodes of vomiting was not significantly different.

Conclusions: Intraperitoneal administration of levobupivacaine with epinephrine is associated with modest analgesia following laparoscopic cholecystectomy.

Keywords

PAIN, postoperativeANAESTHETICS, LOCAL, levobupivacaineSURGERY, laparoscopic cholecystectomyRANDOMIZED CONTROLLED TRIALS
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 8 , August 2004 , pp. 653 - 657
Copyright
2004 European Society of Anaesthesiology

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