Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-02T08:10:28.785Z Has data issue: false hasContentIssue false
  • English
  • Français

Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol

Published online by Cambridge University Press:  16 August 2006

A. Furuya ,
T. Matsukawa ,
M. Ozaki ,
T. Nishiyama ,
M. Kume  and
T. Kumazawa
A. Furuya
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
T. Matsukawa
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
M. Ozaki
Affiliation:
Department of Anaesthesia, Tokyo Women's Medical University
T. Nishiyama
Affiliation:
Surgical Center, The Institute of Medical Science, The University of Tokyo, Tokyo
M. Kume
Affiliation:
Department of Anaesthesia, Kofu Municipal Hospital, Kofu, Japan
T. Kumazawa
Affiliation:
Department of Anaesthesia, Yamanashi Medical University, Yamanashi
Get access

Abstract

Background and objective To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure.

Methods Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthesia was induced with 2 mg kg−1 propofol and 0.5 mg kg−1 ketamine or 2 mg kg−1 propofol alone. Ketamine was administered 1 min prior to induction with propofol. Immediately after induction with propofol, vecuronium (0.15 mg kg−1) was administered. Four minutes after administration of vecuronium, tracheal intubation was performed. Anaesthesia was maintained using sevoflurane (0.5%) in 66% nitrous oxide until 3 min after intubation. Systolic, diastolic and mean arterial pressure and heart rate were recorded on arrival, directly before induction with propofol, prior to tracheal intubation, immediately after intubation and at 3 min after intubation.

Results and conclusions Administration of ketamine before induction with propofol preserved haemodynamic stability compared with induction with propofol alone.

Keywords

anaestheticsintravenousketaminepropofolhaemodynamicsblood pressuredrug effects
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue 2 , February 2001 , pp. 88 - 92
Copyright
2001 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)