Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-27T00:41:12.553Z Has data issue: false hasContentIssue false
  • English
  • Français

Evaluation of the anticoagulant properties of aprotinin in vitro

Published online by Cambridge University Press:  04 August 2006

E. Mortier ,
M. Ongenae ,
J. Van Aken ,
N. Den Blauwen  and
G. Rolly
E. Mortier
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
M. Ongenae
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
J. Van Aken
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
N. Den Blauwen
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
G. Rolly
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
Get access

Abstract

The interaction of aprotinin with normal coagulation was studied in blood samples obtained from 10 healthy subjects. Each sample was simultaneously tested in four different preparations : NaCl-treated blood: 0.03 mL 0.9% NaCl in 0.33 mL blood; aprotinin treated blood : 0.33 mL blood+aprotinin in 0.03 mL in aliquots to obtain a final blood concentration of respectively 50 KIU mL−1; 100 KIU mL−1 and 200 KIU mL−1. The coagulation process was analysed by thromboelastography. R-time, reflecting intrinsic coagulation, increased in a dose dependent manner between NaCl-treated and aprotinin-treated blood. These findings suggest a dose dependent impairment of intrinsic coagulation by aprotinin.

Keywords

coagulationaprotininmeasurement techniquesthromboelastography
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 468 - 470
Copyright
1996 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)