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Efficacy of intrathecal adenosine for postoperative pain relief

Published online by Cambridge University Press:  01 March 2006

M. Sharma ,
M. Mohta  and
R. Chawla
M. Sharma
Affiliation:
University College of Medical Sciences and Guru Teg Bahadur Hospital, Department of Anaesthesiology and Critical Care, Delhi, India
M. Mohta
Affiliation:
University College of Medical Sciences and Guru Teg Bahadur Hospital, Department of Anaesthesiology and Critical Care, Delhi, India
R. Chawla
Affiliation:
University College of Medical Sciences and Guru Teg Bahadur Hospital, Department of Anaesthesiology and Critical Care, Delhi, India
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Extract

Summary

Background and objective: Adenosine, by intravenous and intrathecal routes, is known to alleviate various types of pain. However, the role of intrathecal adenosine in providing postoperative analgesia has not been confirmed. The aim of the present study was to evaluate the efficacy of intrathecal adenosine for postoperative pain relief, and to determine its role for pre-emptive analgesia. Methods: Ninety ASA I and II females, undergoing elective abdominal hysterectomy, were randomly divided into three groups of 30 patients each. Patients in the ‘early adenosine’ group received intrathecal adenosine 1000 μg, 30 min before induction of anaesthesia. Patients in the ‘late adenosine’ group received the same dose before reversal of neuromuscular blockade. Control patients did not receive any test drug. A balanced general anaesthesia technique was used in all patients. Pain intensity scores using a visual analogue scale, sedation scores, time to first rescue analgesic and total morphine requirement were recorded. Results: There was no significant difference in pain intensity scores, sedation scores, total morphine requirements and time to first rescue analgesic among the three groups. Conclusion: Intrathecal adenosine 1000 μg is not effective as an analgesic for postoperative pain relief, and there is no pre-emptive effect.

Keywords

DRUG ADMINISTRATION, intrathecalDRUGS, adenosinePAIN, postoperativeANALGESIA, pre-emptive
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 6 , June 2006 , pp. 449 - 453
Copyright
© 2006 European Society of Anaesthesiology

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