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Effects of fenoldopam on renal blood flow and its function in a canine model of rhabdomyolysis

Published online by Cambridge University Press:  11 July 2005

C. Murray ,
F. Markos ,
H. M. Snow ,
T. Corcoran ,
N. Parfrey  and
G. D. Shorten
C. Murray
Affiliation:
Cork University Hospital and University College Cork, Departments of Anaesthesia and Intensive Care Medicine, Ireland
F. Markos
Affiliation:
University College Cork, Department of Physiology, Cork, Ireland
H. M. Snow
Affiliation:
University College Cork, Department of Physiology, Cork, Ireland
T. Corcoran
Affiliation:
Cork University Hospital and University College Cork, Departments of Anaesthesia and Intensive Care Medicine, Ireland
N. Parfrey
Affiliation:
Cork University Hospital, Department of Histopathology, Cork, Ireland
G. D. Shorten
Affiliation:
Cork University Hospital and University College Cork, Departments of Anaesthesia and Intensive Care Medicine, Ireland
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Extract

Summary

Background and objective: Our hypothesis was that fenoldopam, a selective DA1 agonist, would protect against rhabdomyolysis-induced renal injury.

Methods: We studied the effects of intravenous fenoldopam (0.1–1.0 μg kg−1 min−1) or saline on renal blood flow and function in 10 anaesthetized Labrador dogs in whom rhabdomyolysis and myoglobinuric acute renal failure had been induced by administration of glycerol 50% (10 mL kg−1) intramuscularly. Haemodynamic measurements including renal blood flow and derived parameters of renal function including creatinine clearance were recorded before and for the 30 min following glycerol injection, and during the 3 h following commencement of each infusion. Serum malondialdehyde concentrations were measured before and 15 min after glycerol intramuscularly, and 30 and 150 min after commencement of the infusion.

Results: In the fenoldopam group, creatinine clearance was less than placebo at 1 and 2 h after commencing the infusion (12.7 ± 11.5 versus 31.3 ± 9.9 mL min−1, P = 0.04; 8.5 ± 5.3 versus 20.1 ± 7.4 mL min−1, P = 0.03). A 140-fold increase in serum malondialdehyde concentration occurred in one dog (fenoldopam group).

Conclusion: Fenoldopam increased the severity of the renal injury in this canine model of myoglobinuric acute renal failure.

Keywords

DOPAMINE AGONISTS, fenoldopamKIDNEY DISEASES, acute, kidney failureMUSCULAR DISEASES, rhabdomyolysis
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 9 , September 2003 , pp. 711 - 718
Copyright
© 2003 European Society of Anaesthesiology

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