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The effect of propofol on the neutrophil respiratory burst

Published online by Cambridge University Press:  04 August 2006

P. G. Murphy
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
A. J. Ogilvy
Affiliation:
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester, UK
S. M. Whiteley
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
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Abstract

We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10−5m N-formyl-L-methionyl-L-leucyl-L-phenylalanine.Propofol 1.25, 2.5 and 5.0 × 10−5m inhibited neutrophil chemiluminescence by 29.6, 43.0 and 57.6%, respectively, in neutrophils prepared from healthy adult volunteers, and by 25.5, 37.4 and 54.7% in cells from patients with severe sepsis. We conclude that propofol interferes with the ability of human neutrophils to generate reactive oxygen species.

Type
Original Article
Copyright
1996 European Society of Anaesthesiology

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