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Effect of dexamethasone on motor brachial plexus block with bupivacaine and with bupivacaine-loaded microspheres in a sheep model

Published online by Cambridge University Press:  02 June 2005

J.-P. Estebe ,
P. Le Corre ,
R. Clément ,
L. Du Plessis ,
F. Chevanne ,
R. Le Verge  and
C. Ecoffey
J.-P. Estebe
Affiliation:
Université de Rennes 1, Service d'Anesthésie-Réanimation Chirurgicale 2, Rennes, France
P. Le Corre
Affiliation:
Université de Rennes 1, Laboratoire de Pharmacie Galénique et Biopharmacie, Rennes, France
R. Clément
Affiliation:
Université de Rennes 1, Laboratoire de Pharmacie Galénique et Biopharmacie, Rennes, France
L. Du Plessis
Affiliation:
Université de Rennes 1, Laboratoire de Pharmacie Galénique et Biopharmacie, Rennes, France
F. Chevanne
Affiliation:
Université de Rennes 1, Laboratoire de Pharmacie Galénique et Biopharmacie, Rennes, France
R. Le Verge
Affiliation:
Université de Rennes 1, Laboratoire de Pharmacie Galénique et Biopharmacie, Rennes, France
C. Ecoffey
Affiliation:
Université de Rennes 1, Service d'Anesthésie-Réanimation Chirurgicale 2, Rennes, France
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Summary

Background and objective: It has been suggested that dexamethasone potentiates the sensory block produced by bupivacaine when both drugs are loaded in microspheres. The aim of the study was to evaluate the effect of dexamethasone on the brachial plexus block obtained with plain bupivacaine and bupivacaine-loaded microspheres.

Methods: Dexamethasone alone (Group 5) or added to plain bupivacaine (75 mg) with (Groups 3 and 4) and without pH correction (Group 2) was compared with plain bupivacaine (75 mg; Group 1). The effect of a small dose of dexamethasone (0.42 mg) was then evaluated on the brachial plexus block obtained with bupivacaine (750 mg) as bupivacaine-loaded microspheres (Group 6). Dexamethasone was added either in the suspending medium (Group 7) or incorporated with bupivacaine into microspheres (Group 8). The motor block was evaluated in a plexus brachial sheep model.

Results: Dexamethasone alone did not produce any motor block. When added to plain bupivacaine without pH correction, complete motor block could not be obtained. When the pH was corrected, addition of dexamethasone to plain bupivacaine seemed to delay the onset of motor block and did not prolong its duration, and it had no effect on the pharmacokinetics of bupivacaine. With bupivacaine-loaded microspheres, the duration of complete motor block was reduced when a small dose of dexamethasone was added in the suspending medium. However, the duration of motor block was significantly prolonged when dexamethasone was incorporated with bupivacaine into microspheres.

Conclusions: Despite the delayed onset of motor block, the incorporation of dexamethasone in bupivacaine-loaded microspheres dramatically increases the duration of action (700 ± 485–5160 ± 2136 min), which could be clinically relevant when such a drug-delivery system will be available.

Keywords

ANAESTHESIA, CONDUCTION, nerve blockANAESTHETICS, LOCAL, bupivacaineHORMONES, SYNTHETIC, dexamethasone, glucocorticoids, syntheticINVESTIGATIVE TECHNIQUES, animal, modelsSPINAL NERVES, brachial plexus
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 4 , April 2003 , pp. 305 - 310
Copyright
© 2003 European Society of Anaesthesiology

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References

Curley J, Castillo J, Hotz J, et al. Prolonged regional nerve blockade: injectable biodegradable bupivacaine/polyester microspheres. Anesthesiology 1996; 84: 1401–1410.Google Scholar
Castillo J, Curley J, Hotz J, et al. Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres. Anesthesiology 1996; 85: 1157–1166.Google Scholar
Dräger C, Benziger D, Gao F, Berde CB. Prolonged intercostal nerve blockade in sheep using controlled-release of bupivacaine and dexamethasone from polymer microspheres. Anesthesiology 1998; 89: 969–979.Google Scholar
Estebe JP, Le Corre P, Chevanne F, Cathelineau G, Le Verge R, Ecoffey C. Motor blockade by brachial plexus block in the sheep. Anesthesiology 2000; 93: 291–293.Google Scholar
Estebe JP, Le Corre P, Du Plessis L, et al. The pharmacokinetics and pharmacodynamics of bupivacaine-loaded microspheres on a brachial plexus block model in sheep. Anesth Analg 2001; 93: 447–455.Google Scholar
Bromage PR, Burfoot ME, Crowell DE, Pettigrew RT. Quality of epidural blockade I: influence of physical factors. Br J Anaesth 1964; 36: 342–352.Google Scholar
Le Corre P, Estebe JP, Clement R, et al. Spray-dried bupivacaine-loaded microspheres: in vitro evaluation and biopharmaceutics of bupivacaine following brachial plexus administration in sheep. Int J Pharm 2002; 238: 191–203.Google Scholar
Le Guevello P, Le Corre P, Chevanne F, Le Verge R. High-performance liquid chromatographic determination of bupivacaine in plasma samples for biopharmaceutical studies and applications to seven other local anaesthetics. J Chromatogr 1993; 622: 284–290.Google Scholar
McClean G, Mackle E, Stirling I. The addition of triamcinolone acetonide to bupivacaine has no effect on the quality of analgesia produced by ilioinguinal nerve block. Anaesthesia 1994; 49: 819–820.Google Scholar
Dyhre H, Wallin R, Bjorkman S, Engstrom S, Renck H. Inclusion of lignocaine base into a polar lipid formulation – in vitro release, duration of peripheral nerve block and arterial blood concentration in the rat. Acta Anaesthesiol Scand 2001; 45: 583–589.Google Scholar