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Duration of stabilization of control responses affects the onset and duration of action of rocuronium but not suxamethonium

Published online by Cambridge University Press:  04 August 2006

M. J. J. Symington ,
E. P. McCoy ,
R. K. Mirakhur  and
N. Kumar
M. J. J. Symington
Affiliation:
Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
E. P. McCoy
Affiliation:
Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
R. K. Mirakhur
Affiliation:
Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
N. Kumar
Affiliation:
Department of Anaesthetics, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
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Abstract

The effect of the duration of stabilization of control responses on the onset and duration of clinical relaxation of suxamethonium 1 mg kg−1 and rocuronium 0.6 mg kg−1 were investigated in 90 patients. The control responses were allowed to stabilize for 1, 5, 10, 15 or 20 min prior to administration of rocuronium and for 1, 5, 10 or 15 min prior to suxamethonium. The mean onset time for rocuronium decreased from 150 to 46 s as the duration of stabilization increased from 1 to 20 min (P < 0.001) although the maximal effect was observed within the first 5 min. The average duration of clinical relaxation also increased from 25 to 40 min (P < 0.001). No effect was observed for either variable in the case of suxamethonium.

Keywords

neuromuscular relaxantsrocuroniumsuxamethoniumneuromuscular relaxantsmonitoringpharmacodynamicsonset of effect
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 4 , April 1996 , pp. 377 - 380
Copyright
1996 European Society of Anaesthesiology

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