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Central nervous system inflammation

Published online by Cambridge University Press:  01 February 2008

S. G. Soriano  and
S. Piva
S. G. Soriano*
Affiliation:
Harvard Medical School, Children’s Hospital Boston, Perioperative and Pain Medicine, Boston, MA, USA
S. Piva
Affiliation:
University of Brescia, Department of Anesthesia, Brescia, Italy
*
Correspondence to: Sulpicio G. Soriano, Perioperative and Pain Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA, USA. E-mail: [email protected]; Tel: +1 617 355 6457; Fax: +1 617 730 0894
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Summary

Activation of inflammation is the hallmark of pathological processes that follow acute injury. This process is mediated by inflammatory cytokines and adhesion molecules that reside on the surface of endothelium, leucocyte and inflammatory cells. Attenuation of the adhesion cascade has been the subject of several basic science and clinical trials in the management of neurological injury. This review will highlight the role of adhesion molecules in the evolution of secondary injury after cerebral ischaemia and trauma. Potential therapeutic avenues will then be discussed.

Keywords

SEPSISINFLAMMATIONCYTOKINESCENTRAL NERVOUS SYSTEMCELL ADHESION MOLECULES
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 25 , Issue S42 , February 2008 , pp. 154 - 159
Copyright
Copyright © European Society of Anaesthesiology 2008

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