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An investigation of the effect of ondansetron on time to induction of anaesthesia with thiopentone and propofol

Published online by Cambridge University Press:  16 August 2006

M. Mansfield ,
D. Russell ,
G. N. C. Kenny  and
J. Kinsella
M. Mansfield
Affiliation:
Directorate and University Department of Anaesthesia, Glasgow Royal Infirmary, Castle Street, Glasgow, UK
D. Russell
Affiliation:
Directorate and University Department of Anaesthesia, Glasgow Royal Infirmary, Castle Street, Glasgow, UK
G. N. C. Kenny
Affiliation:
Directorate and University Department of Anaesthesia, Glasgow Royal Infirmary, Castle Street, Glasgow, UK
J. Kinsella
Affiliation:
Directorate and University Department of Anaesthesia, Glasgow Royal Infirmary, Castle Street, Glasgow, UK
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Abstract

In two consecutive, randomized, double-blind studies the effect of ondansetron on the time to induction of anaesthesia with propofol and, subsequently, thiopentone was assessed. In each study 40 patients received either ondansetron 8mg or placebo immediately before induction of anaesthesia with a standardized dose of propofol (2.5 mg kg−1) or thiopentone (5 mg kg−1). Times to induction of anaesthesia were determined by assessing loss of verbal response, motor power and eyelash reflex. There was no difference in either study in times to induction of anaesthesia between immediate pre-treatment with ondansetron or placebo. Side effects were minor and of similar incidence in the ondansetron and placebo groups.

Keywords

ondansetronanaesthetic induction agentspropofolthiopentonPharmacodynamic interactions
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 1 , January 1997 , pp. 24 - 28
Copyright
1997 European Society of Anaesthesiology

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