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Milrinone enhances the contractility of fatigued diaphragm in dogs: a dose-ranging study

Published online by Cambridge University Press:  16 August 2006

Y. Fujii ,
S. Takahashi  and
H. Toyooka
Y. Fujii
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
S. Takahashi
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
H. Toyooka
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
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Abstract

The dose-related effects of milrinone, a phosphodiesterase (PDE) III inhibitor, on the contractility of fatigued diaphragm were studied in dogs. Animals were divided into three groups of eight each. Diaphragmatic fatigue was induced by intermittent supramaximal bilateral electrophrenic stimulation at a frequency of 20 Hz applied for 30 min. After the production of fatigue, Group I received no study drug; Group II was infused with milrinone (50 mg kg−1 loading dose plus 0.2 mg kg−1 min−1 maintenance dose); Group III was infused with milrinone (50 mg kg−1 loading dose plus 0.5 mg kg−1 min−1 maintenance dose). Diaphragmatic contractility was assessed by measurement of transdiaphragmatic pressure. After the fatigue-producing period, transdiaphragmatic pressure at low-frequency stimulation (20-Hz) decreased from the prefatigued values in all groups (P < 0.05), whereas transdiaphragmatic pressure at high-frequency (100-Hz) stimulation did not change. Compared with Group I, transdiaphragmatic pressure to each stimulus increased during milrinone infusion in Groups II and III (P < 0.05). The increase in transdiaphragmatic pressure was greater in Group III than in Group II (P < 0.05). It is concluded that milrinone is associated with a dose-related effect on the contractility of fatigued diaphragm in dogs.

Keywords

ventilationdiaphragmfatiguepharmacologymilrinone
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 9 , September 1999 , pp. 600 - 604
Copyright
1999 European Society of Anaesthesiology

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