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The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings

Published online by Cambridge University Press:  16 August 2006

P. Kelicen ,
U. B. Ismailoglu ,
O. Erdemli  and
I. Sahin-Erdemli
P. Kelicen
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
U. B. Ismailoglu
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
O. Erdemli
Affiliation:
Department of Anaesthesiology, Turkiye Yuksek Ihtisas Hastanesi, Ankara, Turkey
I. Sahin-Erdemli
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
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Abstract

The effect in isolated rat aorta of propofol, thiopentone, midazolam, etomidate and fentanyl on the impairment of endothelium-dependent relaxation by reactive oxygen species is reported. Aortic rings were exposed to reactive oxygen species by the electrolysis of the bathing physiological buffer, and endothelium dependent relaxation in response to acetylcholine was inhibited. This inhibition was countered by incubation before electrolysis with propofol (2 × 10−5 and 6 × 10−5M) or thiopentone (10−5 − 10−5M), but not with midazolam (3 × 10−4M), etomidate (3 × 10−4M) or fentanyl (3 × 10−5M). We suggest that the protective effect of propofol and thiopentone against the loss of endothelium-dependent relaxation caused by reactive oxygen species may be because of their antioxidant and free radical scavenging properties, which could be clinically relevant during surgical procedures in which ischaemia is unavoidable.

Keywords

reactive oxygen speciesanaesthesiaintravenouspropofolthiopentonenitric oxideendotheliumrat aorta
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 3 , May 1997 , pp. 310 - 315
Copyright
1997 European Society of Anaesthesiology

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