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Dose dependent effect of aprotinin on rate of clot formation

Published online by Cambridge University Press:  04 August 2006

S. G. De Hert ,
N. U. Farooqi ,
G. L. Delrue ,
P. W. Ten Broecke ,
K. M. Vermeyen  and
H. F. Adriaensen
S. G. De Hert
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
N. U. Farooqi
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
G. L. Delrue
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
P. W. Ten Broecke
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
K. M. Vermeyen
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
H. F. Adriaensen
Affiliation:
Department of Anaesthesiology, University of Antwerp, Belgium
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Abstract

Forty-eight patients scheduled for elective cardiac surgery were randomly assigned to receive aprotinin in the following doses: 0.2 mg kg−1 (group A), 0.7 mg kg−1 (group B), 1 mg kg−1 (group C) and 1.4 mg kg−1 (group D). Clot formation was analysed by thromboelastography immediately after induction of anaesthesia and again 30 min after administration of aprotinin. Rate of clot formation was assessed using R (reaction time = rate of initial fibrin formation), K (clot formation time = rate of fibrin build-up and cross linking) and angle of clot formation (denoting speed at which solid clot forms). Strength of the clot was assessed by maximal amplitude of clot formation (MA)and % lysis after 30 and 60 min. Significant reduction of R and K times and increase in angle of clot formation was observed in groups A and B. This effect was not apparent in the other groups. In group D, an increase in R time was noted. These findings indicate a dose dependent effect of aprotinin on rate of clot formation with an earlier clot formation at low doses.

Keywords

coagulationaprotininthromboelastography
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 463 - 467
Copyright
1996 European Society of Anaesthesiology

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