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Dexmedetomidine and meperidine prevent postanaesthetic shivering

Published online by Cambridge University Press:  20 January 2006

C. Bicer ,
A. Esmaoglu ,
A. Akin  and
A. Boyaci
C. Bicer
Affiliation:
Erciyes University, Department of Anaesthesiology and Intensive Care, Kayseri, Turkey
A. Esmaoglu
Affiliation:
Erciyes University, Department of Anaesthesiology and Intensive Care, Kayseri, Turkey
A. Akin
Affiliation:
Erciyes University, Department of Anaesthesiology and Intensive Care, Kayseri, Turkey
A. Boyaci
Affiliation:
Erciyes University, Department of Anaesthesiology and Intensive Care, Kayseri, Turkey
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Extract

Summary

Background and objective: This placebo-controlled study was performed to evaluate the efficacy of dexmedetomidine compared with meperidine and placebo in preventing postanaesthetic shivering. Methods: We studied 120 patients (ASA I–II) scheduled for elective abdominal or orthopaedic surgery of about 1–3 h duration. Forty patients in each group randomly received 1 μg kg−1 of dexmedetomidine, 0.5 mg kg−1 of meperidine or saline 0.9% as placebo, intravenously (i.v.). Mean arterial pressure, heart rate, oxygen saturation and central body temperature were measured. Extubation, awakening and orientation times, shivering, pain, recovery and sedation scores were recorded. Results: Postanaesthetic shivering was seen in 22 patients in the placebo group, four patients in the meperidine group and six patients in the dexmedetomidine group. Sedation scores were significantly higher in the dexmedetomidine group compared with meperidine and placebo groups. Both dexmedetomidine and meperidine caused a significantly prolonged extubation and awakening time compared with placebo. Also, dexmedetomidine caused a significantly prolonged orientation time compared with other two groups. Conclusion: Intraoperative intravenously administration of dexmedetomidine 1 μg kg−1 reduces postanaesthetic shivering as does meperidine 0.5 mg kg−1 in patients after major surgery.

Keywords

ANAESTHESIA RECOVERY PERIOD, complications, shiveringDEXMEDETOMIDINEMEPERIDINE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 2 , February 2006 , pp. 149 - 153
Copyright
© 2006 European Society of Anaesthesiology

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References

Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg 1999; 89: 652–658.Google Scholar
Macintyre PE, Pavlin EG, Dwersteg JF. Effect of meperidine on oxygen consumption, carbon dioxide production, and respiratory gas exchange in postanesthesia shivering. Anesth Analg 1987; 66: 751–755.Google Scholar
Mahajan RP, Grover VK, Sharma SL, Singh H. Intraocular pressure changes during muscular hyperactivity after general anesthesia. Anesthesiology 1987; 66: 419–421.Google Scholar
Frank SM, Fleisher LA, Olson KF et al. Multivariate determinants of early postoperative oxygen consumption in elderly patients. Effects of shivering, body temperature, and gender. Anesthesiology 1995; 83: 241–249.Google Scholar
Alfonsi P. Postanaesthetic shivering. Drugs 2001; 61: 2193–2205.Google Scholar
Schwarzkopf KRG, Hoff H, Hartmann M, Fritz HG. A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering. Anesth Analg 2001; 92: 257–260.Google Scholar
Wang JJ, Ho ST, Lee SC, Liu YC. A comparison among nalbuphine, meperidine, and placebo for treating postanesthetic shivering. Anesth Analg 1999; 88: 686–689.Google Scholar
Yared JP, Starr NJ, Hoffmann-Hogg L et al. Dexamethasone decreases the incidence of shivering after cardiac surgery: a randomized, double-blind, placebo-controlled study. Anesth Analg 1998; 87: 795–799.Google Scholar
Talke P, Tayefeh F, Sessler DI, Jeffrey R, Noursalehi M, Richardson C. Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds. Anesthesiology 1997; 87: 835–841.Google Scholar
Doufas AG, Lin CM, Suleman MI et al. Dexmedetomidine and meperidine additively reduce the shivering threshold in humans. Stroke 2003; 34: 1218–1223.Google Scholar
Aldrete JA, Kroulik D. A postanesthetic recovery score. Anesth Analg 1970; 49: 924–934.Google Scholar
Horn EP, Sessler DI, Standl T et al. Non-thermoregulatory shivering in patients recovering from isoflurane or desflurane anesthesia. Anesthesiology 1998; 89: 878–886.Google Scholar
Horn EP, Schroeder F, Wilhelm S et al. Postoperative pain facilitates nonthermoregulatory tremor. Anesthesiology 1999; 91: 979–984.Google Scholar
Wrench IJ, Singh P, Dennis AR, Mahajan RP, Crossley AWA. The minimum effective doses of petidine and doxapram in the treatment of postanaesthetic shivering. Anaesthesia 1997; 52: 32–36.Google Scholar
Horn EP, Standl T, Sessler DI, Knobelsdorff G, Büchs C, Schulte Esch JS. Physostigmine prevents postanesthetic shivering as does meperidine or clonidine. Anesthesiology 1998; 88: 108–113.Google Scholar
Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs 2000; 59: 263–268.Google Scholar
Erkola O, Korttila K, Aho M, Haasio J, Aantaa R, Kallio A. Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy. Anesth Analg 1994; 79: 646–653.Google Scholar
Jalonen J, Hynynen M, Kuitunen A et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 1997; 86: 331–345.Google Scholar