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Published online by Cambridge University Press: 26 January 2006
This paper contains a short overview of the chemistry of interstellar clouds based on radio astronomical measurements. First, an account of the properties of the Interstellar Medium (ISM) is followed by a historical review up to the time of the discovery of complex molecules. This is followed by a list of molecules and a short collection of molecular abundances, followed by an account of possible chemistries in molecular clouds, and finally, examples of typical galactic sources.