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Nonparametric estimation of the density of the alternative hypothesis in a multiple testing setup. Application to local false discovery rate estimation

Published online by Cambridge University Press:  15 October 2014

Van Hanh Nguyen  and
Catherine Matias
Van Hanh Nguyen
Affiliation:
Laboratoire de Mathématiques d’Orsay, Université Paris Sud, UMR CNRS 8628, Bâtiment 425, 91405 Orsay cedex, France. [email protected] Laboratoire Statistique et Génome, Université d’Évry Val d’Essonne, UMR CNRS 8071, USC INRA, 23 bvd de France, 91037 Évry, France; [email protected]
Catherine Matias
Affiliation:
Laboratoire Statistique et Génome, Université d’Évry Val d’Essonne, UMR CNRS 8071, USC INRA, 23 bvd de France, 91037 Évry, France; [email protected]
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Abstract

In a multiple testing context, we consider a semiparametric mixture model with two components where one component is known and corresponds to the distribution of p-values under the null hypothesis and the other component f is nonparametric and stands for the distribution under the alternative hypothesis. Motivated by the issue of local false discovery rate estimation, we focus here on the estimation of the nonparametric unknown component f in the mixture, relying on a preliminary estimator of the unknown proportion θ of true null hypotheses. We propose and study the asymptotic properties of two different estimators for this unknown component. The first estimator is a randomly weighted kernel estimator. We establish an upper bound for its pointwise quadratic risk, exhibiting the classical nonparametric rate of convergence over a class of Hölder densities. To our knowledge, this is the first result establishing convergence as well as corresponding rate for the estimation of the unknown component in this nonparametric mixture. The second estimator is a maximum smoothed likelihood estimator. It is computed through an iterative algorithm, for which we establish a descent property. In addition, these estimators are used in a multiple testing procedure in order to estimate the local false discovery rate. Their respective performances are then compared on synthetic data.

Keywords

False discovery ratekernel estimationlocal false discovery ratemaximum smoothed likelihoodmultiple testingp-valuessemiparametric mixture model
Type
Research Article
Information
ESAIM: Probability and Statistics , Volume 18 , 2014 , pp. 584 - 612
Copyright
© EDP Sciences, SMAI, 2014

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