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Exercise stress, intestinal permeability and gastric ulceration in racing Alaskan sled dogs

Published online by Cambridge University Press:  09 March 2007

Christopher M Royer ,
Michael Willard ,
Katherine Williamson ,
Jörg M Steiner ,
David A Williams  and
Michael David
Christopher M Royer
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74 078, USA
Michael Willard
Affiliation:
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA
Katherine Williamson
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74 078, USA
Jörg M Steiner
Affiliation:
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA
David A Williams
Affiliation:
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA
Michael David*
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74 078, USA
*
*Corresponding author: [email protected]
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Abstract

Sustained strenuous exercise has been shown to produce gastrointestinal disease in athletic species, but the causative factors remain unknown. Since exercise results in oxidative stress and hypercortisolaemia, we tested the hypothesis that oxidative and physiological stress cause gastrointestinal disease in racing Alaskan sled dogs. Dogs from three racing teams were examined before (pre) and immediately after (post) completing a 1770-km sled dog race in approximately 11 days. Serum cortisol and isoprostane concentrations were compared with markers of gastrointestinal barrier integrity and endoscopic evidence of gastric ulceration. Gastric barrier integrity was assessed by measuring the urinary recovery of sucrose and intestinal barrier integrity was assessed using the urinary recovery ratio of lactulose to rhamnose (L/R), administered together by orogastric gavage. Exercise produced a significant increase in median serum cortisol (pre: 1040, 717–2946 pg ml−1 (range); post: 8072, 2228–29 571 pg ml−1; P<0.0001) and L/R recovery ratio (pre: 0.110, 0.060–0.270; post: 0.165, 0.080–0.240; P=0.009) but not isoprostane (pre: 1007, 656–2305 pg ml−1; post: 1164, 23–4710 pg ml−1; P=0.194) concentration. The increased serum cortisol concentration was not correlated with a change in L/R recovery ratio or urine sucrose concentration. Dogs with abnormal gastric endoscopy results (61% of finishers) had higher serum cortisol concentrations than dogs with normal endoscopy results (P=0.0007). We have demonstrated concurrent hypercortisolaemia and gastrointestinal barrier dysfunction with no correlation of the two. Thus, our data do not provide support for the hypothesis that increased serum cortisol concentration causes exercise-induced gastrointestinal disease.

Keywords

gastric ulcerintestinal permeabilityexercisecortisol
Type
Research Paper
Information
Equine and Comparative Exercise Physiology , Volume 2 , Issue 1 , February 2005 , pp. 53 - 59
Copyright
Copyright © Cambridge University Press 2005

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