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Acute vascular occlusion in horses: effects on skeletal muscle size and blood flow

Published online by Cambridge University Press:  09 March 2007

T Abe ,
CF Kearns ,
HC Manso Filho ,
Y Sato ,
M Sleeper  and
KH McKeever
T Abe*
Affiliation:
Department of Exercise and Sport Science, Tokyo Metropolitan University, 1-1 Minami-Ohsawa, Hachioji, Tokyo, 192-0397, Japan
CF Kearns
Affiliation:
Cardiovascular/Endocrine Biology, Schering-Plough Research Institute, Kenilworth, NJ, USA
HC Manso Filho
Affiliation:
Equine Science Center, Department of Animal Sciences, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
Y Sato
Affiliation:
Sato Institute for Rehabilitation and Fitness, Fuchu, Tokyo, Japan
M Sleeper
Affiliation:
Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA
KH McKeever
Affiliation:
Equine Science Center, Department of Animal Sciences, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
*
Email:[email protected]
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Abstract

The purpose of this study was to demonstrate whether acute vascular occlusion was safe and if it would result in changes to limb muscle size in horses. Six healthy, unfit Standardbred mares were used. Horses (standing at rest) wore an occlusion cuff at the most proximal position of the left forelimb. The right forelimb was used as control. An occlusion pressure of 200 mmHg was set for 5 min followed by a 2 min recovery. Three sets of occlusions were given to each horse. Muscle thickness was measured using B-mode ultrasound. The circumference of the forelimb and first phalanx was measured using a flexible tape measure. Pulsed-wave Doppler was performed on the radialis artery with a 5–10 MHz mechanical transducer at baseline and at each occlusion. Peak flow velocity (PFV) and the flow velocity integral (FVI) were measured each time. Mid-forelimb, but not first phalanx, girth was increased (P<0.05) in the occluded but not in the control leg following occlusion. Extensor and flexor muscle thickness was increased (P<0.05) in the occluded but not in the control leg. There were no changes (P>0.05) in PFV or FVI at any measurement time point. Acute vascular occlusion may be a suitable and safe model for studying muscle hypertrophy in horses.

Keywords

muscle thicknessplasma lactatepacked cell volumeKaatsu-training
Type
Short Communication
Information
Equine and Comparative Exercise Physiology , Volume 1 , Issue 4 , November 2004 , pp. 239 - 243
Copyright
Copyright © Cambridge University Press 2004

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