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Psychosis Incident Cohort Outcome Study (PICOS). A multisite study of clinical, social and biological characteristics, patterns of care and predictors of outcome in first-episode psychosis. Background, methodology and overview of the patient sample

Published online by Cambridge University Press:  15 June 2012

A. Lasalvia ,
S. Tosato ,
P. Brambilla ,
M. Bertani ,
C. Bonetto ,
D. Cristofalo ,
S. Bissoli ,
K. De Santi ,
L. Lazzarotto  and
G. Zanatta
...Show all authors
A. Lasalvia*
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
S. Tosato
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
P. Brambilla
Affiliation:
DISM, Inter-University Centre for Behavioural Neurosciences, University of Udine, Udine, Italy and Scientific Institute IRCCS ‘E. Medea’, Udine, Italy
M. Bertani
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
C. Bonetto
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
D. Cristofalo
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
S. Bissoli
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
K. De Santi
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
L. Lazzarotto
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
G. Zanatta
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
G. Marrella
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
R. Mazzoncini
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
M. Zanoni
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
N. Garzotto
Affiliation:
Department of Mental Health, 1st Psychiatric Service, ULSS 20, Verona, Italy
C. Dolce
Affiliation:
Department of Mental Health, ULSS 6, Vicenza, Italy
S. Nicolau
Affiliation:
Department of Mental Health, ULSS 22, Isola d/S, VR, Italy
L. Ramon
Affiliation:
Department of Mental Health, ULSS 10, Portogruaro, VE, Italy
C. Perlini
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
G. Rambaldelli
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
M. Bellani
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
M. Tansella
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
M. Ruggeri
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
*
*Address for correspondence: Dr Antonio Lasalvia, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Policlinico ‘G.B. Rossi’, Piazzale L. A. Scuro 10, 37134-Verona, Italy. (Email: [email protected])
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Abstract

Aims.

This paper aims at providing an overview of the background, design and initial findings of Psychosis Incident Cohort Outcome Study (PICOS).

Methods.

PICOS is a large multi-site population-based study on first-episode psychosis (FEP) patients attending public mental health services in the Veneto region (Italy) over a 3-year period. PICOS has a naturalistic longitudinal design and it includes three different modules addressing, respectively, clinical and social variables, genetics and brain imaging. Its primary aims are to characterize FEP patients in terms of clinical, psychological and social presentation, and to investigate the relative weight of clinical, environmental and biological factors (i.e. genetics and brain structure/functioning) in predicting the outcome of FEP.

Results.

An in-depth description of the research methodology is given first. Details on recruitment phase and baseline and follow-up evaluations are then provided. Initial findings relating to patients' baseline assessments are also presented. Future planned analyses are outlined.

Conclusions.

Both strengths and limitations of PICOS are discussed in the light of issues not addressed in the current literature on FEP. This study aims at making a substantial contribution to research on FEP patients. It is hoped that the research strategies adopted in PICOS will enhance the convergence of methodologies in ongoing and future studies on FEP.

Keywords

First-episode psychosisoutcomefollow-up studygeneticspredictorsbrain imaging
Type
Original Articles
Information
Epidemiology and Psychiatric Sciences , Volume 21 , Issue 3 , September 2012 , pp. 281 - 303
Copyright
Copyright © Cambridge University Press 2012

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References

Addington, J, Chaves, A, Addington, D (2006). Diagnostic stability over one year in first-episode psychosis. Schizophrenia Research 86, 71–75.CrossRefGoogle ScholarPubMed
Alkelai, A, Baum, A, Carless, M, Crowley, J, Dasbanerjee, T, Dempster, E, Docherty, S, Hare, E, Galsworthy, MJ, Grover, D, Glubb, D, Karlsson, R, Mill, J, Sen, S, Quinones, MP, Vallender, EJ, Verma, R, Vijayan, NN, Villafuerte, S, Voineskos, AN, Volk, H, Yu, L, Zimmermann, P, DeLisi, LE (2008). The XVth World Congress of Psychiatric Genetics, October 7–11, 2007: Rapporteur summaries of oral presentations. American Journal of Medical Genetic, Part B Neuropsychiatric Genetics 147B, 233–277.CrossRefGoogle ScholarPubMed
Allen, NC, Bagade, S, McQueen, MB, Ioannidis, JP, Kavvoura, FK, Khoury, MJ, Tanzi, RE, Bertram, L (2008). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics 40, 827–834.CrossRefGoogle ScholarPubMed
Amaddeo, F, Zambello, F, Tansella, M, Thornicroft, G (2001). Accessibility and pathways to psychiatric care in a community-based mental health system. Social Psychiatry and Psychiatric Epidemiology 36, 500–507.CrossRefGoogle Scholar
American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder (DSM-IV), 4th edn.APA: Washington.Google Scholar
Arango, C, Moreno, C, Martínez, S, Parellada, M, Desco, M, Moreno, D, Fraguas, D, Gogtay, N, James, A, Rapoport, J (2008). Longitudinal brain changes in early-onset psychosis. Schizophrenia Bulletin 34, 341–353.CrossRefGoogle ScholarPubMed
Barnes, TRE (1989). A rating scale for drug-induced akathisia. British Journal of Psychiatry 154, 672–676.CrossRefGoogle ScholarPubMed
Bech, P, Rafaelsen, OJ, Kramp, P, Bolwig, TG (1978). The Mania Rating Scale: scale construction and inter-observer agreement. Neuropharmacology 6, 420–431.Google Scholar
Bechara, A, Damasio, A, Damasio, H, Anderson, S (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7–15.CrossRefGoogle ScholarPubMed
Bellani, M, Marzi, CA, Savazzi, S, Perlini, C, Cerruti, S, Ferro, A, Marinelli, V, Sponda, S, Rambaldelli, G, Tansella, M, Brambilla, P (2010). Laterality effects in schizophrenia and bipolar disorder. Experimental Brain Research 201, 339–344.CrossRefGoogle ScholarPubMed
Bergen, SE, Petryshen, TL (2012). Genome-wide association studies of schizophrenia: does bigger lead to better results? Current Opinion in Psychiatry 25, 76–82.CrossRefGoogle ScholarPubMed
Bertani, M, Lasalvia, A, Bonetto, C, Tosato, S, Cristofalo, D, Bissoli, S, De Santi, K, Mazzoncini, R, Lazzarotto, L, Santi, M, Sale, A, Scalabrin, D, Abate, M, Tansella, M, Ruggeri, M, on behalf of PICOS-Veneto Group (2012). The influence of gender on clinical and social characteristics of patients at psychosis onset: a report from the Psychosis Incident Cohort Outcome Study (PICOS). Psychological Medicine 42, 769–782.CrossRefGoogle ScholarPubMed
Bottlender, R, Jaeger, M, Groll, C, Strauss, A, Moeller, HJ (2001). Deficit states in schizophrenia and their association with the length of illness and gender. European Archives of Psychiatry and Clinical Neuroscience 251, 272–278.CrossRefGoogle ScholarPubMed
Bromet, EJ, Naz, B, Fochtmann, LJ, Carlson, GA, Tanenberg-Karant, M (2005). Long-term diagnostic stability and outcome in recent first-episode cohort studies of schizophrenia. Schizophrenia Bulletin 31, 639–649.CrossRefGoogle ScholarPubMed
Buchanan, RW, Heinrichs, DW (1989). The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Research 27, 335–350.CrossRefGoogle Scholar
Cahn, W, Hulshoff Pol, HE, Lems, EB, van Haren, NE, Schnack, HG, van der Linden, JA, Schothorst, PF, van Engeland, H, Kahn, RS (2002). Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Archives of General Psychiatry 59, 1002–1010.CrossRefGoogle ScholarPubMed
Carpenter, WT Jr., Buchanan, RW, Kirkpatrick, B, Tamminga, C, Wood, F (1993). Strong inference, theory testing, and the neuroanatomy of schizophrenia. Archives of General Psychiatry 50, 25–831.CrossRefGoogle ScholarPubMed
Colombo, L, Sartori, G, Brivio, C (2002). Stima del Quoziente Intellettivo tramite l'applicazione del TIB (Test Breve di Intelligenza). Giornale Italiano di Psicologia 29, 613–637.Google Scholar
Cook, EH, Scherer, SW (2008). Copy-number variations associated with neuropsychiatric conditions. Nature 455, 919–923.CrossRefGoogle ScholarPubMed
David, AS, Buchanan, A, Reed, A, Almeida, O (1992). The assessment of insight in psychosis. British Journal of Psychiatry 161, 599–602.CrossRefGoogle ScholarPubMed
DeLisi, LE, Hoff, AL (2005). Failure to find progressive temporal lobe volume decreases 10 years subsequent to a first episode of schizophrenia. Psychiatry Research 138, 265–268.CrossRefGoogle ScholarPubMed
DeLisi, LE, Sakuma, M, Maurizio, AM, Relja, M, Hoff, AL (2004). Cerebral ventricular change over the first 10 years after the onset of schizophrenia. Psychiatry Research 130, 57–70.CrossRefGoogle ScholarPubMed
DeRosse, P, Funke, B, Burdick, KE, Lencz, T, Ekholm, JM, Kane, JM, Kucherlapati, R, Malhotra, AK (2006). Dysbindin genotype and negative symptoms in schizophrenia. American Journal of Psychiatry 163, 532–534.CrossRefGoogle ScholarPubMed
de Salvia, D, Barbato, A, Salvo, P, Zadro, F (1993). Prevalence and incidence of schizophrenic disorders in Portogruaro. An Italian case register study. Journal of Nervous and Mental Disease 181, 275–82.CrossRefGoogle ScholarPubMed
Edwards, J, McGorry, PD (2002). Implementing Early Intervention in Psychosis. Martin Dunitz: London.CrossRefGoogle Scholar
Emsley, R, Chiliza, B, Schoeman, R (2008). Predictors of long-term outcome in schizophrenia. Current Opinion in Psychiatry 21, 173–177.CrossRefGoogle ScholarPubMed
Estes, WD, Taylor, HA (1964). A detection method and probabilistic models for assessing information processing from brief visual displays. Proceedings of the National Academy of Sciences of the United States of America 52, 446–454.CrossRefGoogle Scholar
Fearon, P, Kirkbride, JB, Morgan, C, Dazzan, P, Morgan, K, Lloyd, T, Hutchinson, G, Tarrant, J, Fung, WL, Holloway, J, Mallett, R, Harrison, G, Leff, J, Jones, PB, Murray, RM, ÆSOP Study Group (2006). Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC ÆSOP study. Psychological Medicine 36, 1541–1550.CrossRefGoogle ScholarPubMed
Foerster, A, Lewis, S, Owen, M, Murray, R (1991). Pre-morbid adjustment and personality in psychosis: effects of sex and diagnosis. British Journal of Psychiatry 158, 171–176.CrossRefGoogle ScholarPubMed
Folstein, MF, Folstein, SE, McHugh, PR (1975). ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12: 189–198.CrossRefGoogle Scholar
Fowler, D, Rollinson, R, French, P (2011). Adherence and competence assessment in studies of CBT for psychosis: current status and future directions. Epidemiology and Psychiatric Sciences 20, 121–126.CrossRefGoogle ScholarPubMed
Friis, S, Larsen, TK, Melle, I, Opjordsmoen, S, Johannessen, JO, Haahr, U, Simonsen, E, Rund, BR, Vaglum, P, McGlashan, T (2003). Methodological pitfalls in early detection studies – the NPE Lecture 2002. Nordic Association for Psychiatric Epidemiology. Acta Psychiatrica Scandinavica 107, 3–9.CrossRefGoogle Scholar
Gogtay, N, Vyas, NS, Testa, R, Wood, SJ, Pantelis, C (2011). Age of onset of schizophrenia: perspectives from structural neuroimaging studies. Schizophrenia Bulletin 37, 504–513.CrossRefGoogle ScholarPubMed
Goldberg, D, Williams, P (1988). A User's Guide to the General Health Questionnaire. NFER-Nelson: Windsor.Google Scholar
Grant, C, Addington, J, Addington, D, Konnert, C (2001). Social functioning in first and multiepisode schizophrenia. Canadian Journal of Psychiatry 46, 746–749.CrossRefGoogle ScholarPubMed
Hamilton, M (1960). A rating scale for depression. Journal of Neurology Neurosurgery and Psychiatry 23, 56–62.CrossRefGoogle ScholarPubMed
Harris, A, Brennan, J, Anderson, J, Taylor, A, Sanbrook, M, Fitzgerald, D, Lucas, S, Redoblado-Hodge, A, Gomes, L, Gordon, E (2005). Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. Australian and New Zealand Journal of Psychiatry 39, 36–43.CrossRefGoogle ScholarPubMed
Harrison, PJ, Lewis, DA (2003). Neuropathology of schizophrenia. In Schizophrenia, 2nd edn (ed. Hirsch, SR and Weinberger, DR), pp. 310–325. Blackwell Science Ltd: Oxford.CrossRefGoogle ScholarPubMed
Heaton, RK (1981). Wisconsin Card Sorting Test Manual. Psychological Assessment Resources. Psychological Assessment Resources: Odessa, FL.Google Scholar
Ho, BC, Andreasen, NC, Nopoulos, P, Arndt, S, Magnotta, V, Flaum, M (2003). Progressive structural brain abnormalities and their structural relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Archives of General Psychiatry 60, 585–594.CrossRefGoogle ScholarPubMed
Hox, J (2002). Multilevel Analysis. Techniques and Applications. Lawrence Erlbaum Associates Inc., Publishers: Mahwah, NJ.CrossRefGoogle Scholar
Jablensky, A (2006). Subtyping schizophrenia: implications for genetic research. Molecular Psychiatry 11, 815–836.CrossRefGoogle ScholarPubMed
Jablensky, A, Sartorius, N, Ernberg, G, Anker, M, Korten, A, Cooper, JE, Day, R, Bertelsen, A (1992). Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine, Monograph Supplement 20, 1–97.CrossRefGoogle ScholarPubMed
Jackson, C, Bernard, M, Birchwood, M (2011). The efficacy of psychotherapy in reducing post-psychotic trauma. Epidemiology Psychiatric Sciences 20, 127–131.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LA (1987). The Positive and Negative Syndrome Scale for schizophrenia. Schizophrenia Bulletin 13, 261–276.CrossRefGoogle ScholarPubMed
Kirchner, WK (1958). Age differences in short-term retention of rapidly changing information. Journal of Experimental Psychology 55, 352–358.CrossRefGoogle ScholarPubMed
Larsen, TK, Friis, S, Haahr, U, Johannessen, JO, Melle, I, Opjordsmoen, S, Rund, BR, Simonsen, E, Vaglum, PV, McGlashan, TH (2004). Premorbid adjustment in first-episode non-affective psychosis: distinct patterns of pre-onset course. British Journal of Psychiatry 185, 108–115.CrossRefGoogle ScholarPubMed
Lasalvia, A, Ruggeri, M (2007). Assessing the outcome of community-based psychiatric care: building a feed-back loop from ‘real world’ services research into clinical practice. Acta Psychiatrica Scandinavica 116 (Suppl. 437), 6–15.CrossRefGoogle Scholar
Lasalvia, A, Tansella, M (2010). Acute in-patient care in modern, community-based mental health services. Where and how? Epidemiologia e Psichiatria Sociale 19, 275–281.CrossRefGoogle ScholarPubMed
Lasalvia, A, Bonetto, C, De Santi, K, Ruggeri, M (2004). Patterns of clinical course in persons with mental disorders: which impact on social disability and quality of life? A longitudinal study (Italian). Epidemiologia e Psichiatria Sociale 13, 169–190.CrossRefGoogle Scholar
Lasalvia, A, Gentile, B, Ruggeri, M, et al. (2007). Heterogeneity of the Departments of Mental Health in the Veneto Region ten years after the National Plan 1994–96 for Mental Health. Which implication for clinical practice? Findings from the PICOS Project (Italian). Epidemiologia e Psichiatria Sociale 16, 59–70.CrossRefGoogle Scholar
Lasalvia, A, Bonetto, C, Bertani, M, Bissoli, S, Cristofalo, D, Marrella, G, Ceccato, E, Cremonese, C, De Rossi, M, Lazzarotto, L, Marangon, V, Morandin, I, Zucchetto, M, Tansella, M, Ruggeri, M (2009). Influence of perceived organizational factors on job burnout: survey of community mental health staff. British Journal of Psychiatry 195, 537–544.CrossRefGoogle ScholarPubMed
Leyland, AH, Goldestein, H (2003). Multilevel Modeling of Health Statistics. John Wiley & Sons: New York, NY.Google Scholar
Liddle, PF, Pantelis, C (2003). Brain imaging in schizophrenia. In Schizophrenia, 2nd edn (ed. Hirsch, SR and Weinberger, DR), pp. 403–417. Blackwell Science Ltd: Oxford.CrossRefGoogle Scholar
Little, RJA, Rubin, DB (2002). Statistical Analysis with Missing Data, Second editionNew York: Wiley.CrossRefGoogle Scholar
Maier, W (2008). Common risk genes for affective and schizophrenic psychoses. European Archives of Psychiatry and Clinical Neuroscience 258 (Suppl. 2), 37–40.CrossRefGoogle ScholarPubMed
Malla, A, Payne, J (2005). First-episode psychosis: psychopathology, quality of life, and functional outcome. Schizophrenia Bulletin 31, 650–671.CrossRefGoogle ScholarPubMed
Malla, A, Norman, RM (2006). The Canadian National Outcomes Study in Schizophrenia – Preface. Acta Psychiatrica Scandinavica 113 (Suppl. 430), 3.Google Scholar
Malla, AK, Takhar, JJ, Norman, RM, Manchanda, R, Cortese, L, Haricharan, R, Verdi, M, Ahmed, R (2002). Negative symptoms in first episode non-affective psychosis. Acta Psychiatrica Scandinavica 105, 431–439.CrossRefGoogle ScholarPubMed
Marzi, CA (1999). The Poffenberger paradigm: a first, simple, behavioural tool to study interhemispheric transmission in humans. Brain Research Bulletin 50, 421–422.CrossRefGoogle ScholarPubMed
Maxwell, E (1992). Manual for the Family Interview for Genetics Studies. Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health: Bethesda, MD.Google Scholar
McCrone, P, Leese, M, Thornicroft, G, Schene, A, Knudsen, HC, Vazquez Barquero, JL, Lasalvia, A, Padfield, S, White, IR, Griffiths, G, the EPSILON Study Group (2000). The reliability of the Camberwell Assessment of Need-European Version. EPSILON Study 6. British Journal of Psychiatry 177 (Suppl. 39), 34–40.CrossRefGoogle Scholar
McGlashan, TH, Carpenter, WT Jr, Bartko, JJ (1988). Issues of design and methodology in long-term followup studies. Schizophrenia Bulletin 14, 569–574.CrossRefGoogle ScholarPubMed
McGorry, PD, Krstev, H, Harrigan, S (2000). Early detection and treatment delay: implications for outcome in early psychosis. Current Opinion in Psychiatry 13, 37–43.CrossRefGoogle Scholar
Menezes, NM, Arenovich, T, Zipursky, RB (2006). A systematic review of longitudinal outcome studies of first-episode psychosis. Psychological Medicine 36, 1349–1362.CrossRefGoogle ScholarPubMed
Morgan, C, Dazzan, P, Morgan, K, Jones, P, Harrison, G, Leff, J, Murray, R, Fearon, P, ÆSOP Study Group (2006). First episode psychosis and ethnicity: initial findings from the ÆSOP study. World Psychiatry 5, 40–46.Google ScholarPubMed
Moritz, S, Lambert, M, Andresen, B, Bothern, A, Naber, D, Krausz, M (2001). Subjective cognitive dysfunction in first-episode and chronic schizophrenic patients. Comprehensive Psychiatry 42, 213–216.CrossRefGoogle ScholarPubMed
Moritz, S, Andresen, B, Perro, C, Schickel, M, Kraus, M, Naber, D, PERSIST Study Group (2002). Neurocognitive performance in first episode and chronic schizophrenic patients. European Archives of Psychiatry and Clinical Neuroscience 252, 33–37.CrossRefGoogle ScholarPubMed
Mueser, KT, Nishith, P, Tracy, JI, DeGirolamo, J, Molinaro, M. (1995). Expectations and motives for substance use in schizophrenia. Schizophrenia Bulletin 21, 367–378.CrossRefGoogle ScholarPubMed
Nasrallah, H, Tandon, R, Keshavan, M (2011). Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment. Epidemiology and Psychiatric Sciences 20, 317–327.CrossRefGoogle Scholar
Nelson, HE (1982). National Adult Heading Test (NART): Test Manual. NFER-Nelson: Windsor.Google Scholar
Norman, RM, Malla, AK (2001). Duration of untreated psychosis: a critical examination of the concept and its importance. Psychological Medicine 31, 381–400.CrossRefGoogle ScholarPubMed
Nuechterlein, KH (1991). Vigilance in schizophrenia and related disorders. In Handbook of Schizophrenia. Vol. 5: Neuropsychology, Psychophysiology and Information Processing (ed. Seinhauer, SR, Gruzelier, JH and Zubin, J), pp. 397–433. Elsevier Science Publisher: New York, NY.Google Scholar
Onwumere, J, Bebbington, P, Kuipers, E (2011). Family interventions in early psychosis: specificity and effectiveness. Epidemiology Psychiatric Sciences 20, 113–119.CrossRefGoogle ScholarPubMed
Pantelis, C, Yücel, M, Wood, SJ, Velakoulis, D, Sun, D, Berger, G, Stuart, GW, Yung, A, Phillips, L, McGorry, PD (2005). Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophrenia Bulletin 31, 672–696.CrossRefGoogle ScholarPubMed
Papagno, C, Cappa, SF, Capitani, E, Forelli, A, Garavaglia, G, Laiacona, M, Capitani, E, Vallar, G (1995). La comprensione non letterale del linguaggio: taratura di un test di comprensione di metafore e di espressioni idiomatiche. Archivio di Psicologia, Neurologia e Psichiatria 56, 402–420.Google Scholar
Parker, G, Tupling, H, Brown, LB (1979). A parental bonding instrument. British Journal of Medical Psychology 52, 1–10.CrossRefGoogle Scholar
Price, G, Cercignani, M, Bagary, MS, Barnes, TR, Barker, GJ, Joyce, EM, Ron, MA (2006). A volumetric MRI and magnetization transfer imaging follow-up study of patients with first-episode schizophrenia. Schizophrenia Research 87, 100–108.CrossRefGoogle ScholarPubMed
Priebe, S, Huxley, P, Knight, S, Evans, S (1999). Application and results of the Manchester Short Assessment of Quality of Life (MANSA). International Journal of Social Psychiatry 45, 7–12.CrossRefGoogle ScholarPubMed
Ram, R, Bromet, EJ, Eaton, WW, Pato, C, Schwartz, JE (1992). The natural course of schizophrenia: a review of first-admission studies. Schizophrenia Bulletin 18, 185–207.CrossRefGoogle ScholarPubMed
Raven, J, Raven, JC, Court, JH (2003). Manual for Raven's Progressive Matrices and Vocabulary Scales. Section 1: General Overview. Harcourt Assessment: San Antonio, TX.Google Scholar
Rietkerk, T, Boks, MP, Sommer, IE, Liddle, PF, Ophoff, RA, Kahn, RS (2008). The genetics of symptom dimensions of schizophrenia: review and meta-analysis. Schizophrenia Research 102, 197–205.CrossRefGoogle ScholarPubMed
Ruggeri, M, Lasalvia, A, Dall'Agnola, R, Wijngaarden van, B, Knudsen, HC, Leese, M, Gaite, L, Tansella, M, the EPSILON Study Group (2000). Development, internal consistency and reliability of the Verona Service Satisfaction Scale-European Version. EPSILON Study 7. British Journal of Psychiatry 177 (Suppl. 39), 41–48.CrossRefGoogle Scholar
Ruggeri, M, Lasalvia, A, Tansella, M, Bonetto, C, Abate, M, Thornicroft, G, Allevi, L, Ognibene, P (2004). Heterogeneity of outcomes in schizophrenia: 3-year follow-up of treated prevalent cases. British Journal of Psychiatry 184, 48–57.CrossRefGoogle ScholarPubMed
Ruggeri, M, Salvi, G, Bonetto, C, Lasalvia, A, Allevi, L, Parabiaghi, A, Bertani, M, Tansella, M (2007). Outcome of patients dropping out from community-based mental health care: a 6-year multiwave follow-up study. Acta Psychiatrica Scandinavica 116 (Suppl. 437), 42–52.CrossRefGoogle Scholar
Salvatore, P, Baldessarini, RJ, Tohen, M, Khalsa, HM, Sanchez-Toledo, JP, Zarate, CA Jr, Vieta, E, Maggini, C (2009). McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients. Journal of Clinical Psychiatry 70, 458–466.CrossRefGoogle ScholarPubMed
Sanders, AR, Duan, J, Levinson, DF, Shi, J, He, D, Hou, C, Burrell, GJ, Rice, JP, Nertney, DA, Olincy, A, Rozic, P, Vinogradov, S, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Crowe, RR, Cloninger, CR, Martinez, M, Gejman, PV (2008). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. American Journal of Psychiatry 165, 497–506.CrossRefGoogle Scholar
Shenton, ME, Dickey, CC, Frumin, M, McCarley, RW (2001). A review of MRI findings in schizophrenia. Schizophrenia Research 49, 1–52.CrossRefGoogle ScholarPubMed
Shi, Y, Li, Z, Xu, Q, Wang, T, Li, T, Shen, J, Zhang, F, Chen, J, Zhou, G, Ji, W, Li, B, Xu, Y, Liu, D, Wang, P, Yang, P, Liu, B, Sun, W, Wan, C, Qin, S, He, G, Steinberg, S, Cichon, S, Werge, T, Sigurdsson, E, Tosato, S, Palotie, A, Nöthen, MM, Rietschel, M, Ophoff, RA, Collier, DA, Rujescu, D, Clair, DS, Stefansson, H, Stefansson, K, Ji, J, Wang, Q, Li, W, Zheng, L, Zhang, H, Feng, G, He, L (2011). Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genet ics 43, 1224–1227.CrossRefGoogle ScholarPubMed
Simpson, GN, Angus, JWS (1970). A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica 212 (Suppl. 44), 11–19.CrossRefGoogle ScholarPubMed
Steen, RG, Mull, C, McClure, R, Hamer, RM, Lieberman, JA (2006). Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. British Journal of Psychiatry 188, 510–518.CrossRefGoogle ScholarPubMed
Sullivan, PF (2008). The dice are rolling for schizophrenia genetics. Psychological Medicine 38, 1693–1696.CrossRefGoogle ScholarPubMed
Tansella, M, Balestrieri, M, Meneghelli, G, Micciolo, R (1991). Trends in the provision of psychiatric care 1979–1988. In From Community-Based Psychiatry: Long Term Patterns of Care in South-Verona (ed. Tansella, M), pp. 5–16. Psychological Medicine, Monograph Supplement 19. Cambridge University Press: CambridgeGoogle Scholar
Tansella, M, Amaddeo, F, Burti, L, Lasalvia, A, Ruggeri, M (2006). Evaluating a community-based mental health service focusing on severe mental illness. The Verona experience. Acta Psychiatrica Scandinavica 113 (Suppl. 429), 90–94.CrossRefGoogle Scholar
Tello, JE, Mazzi, M, Tansella, M, Bonizzato, P, Jones, J, Amaddeo, F (2005). Does socioeconomic status affect the use of community-based psychiatric services? A South Verona case register study. Acta Psychiatrica Scandinavica 112, 215–223.CrossRefGoogle ScholarPubMed
Tosato, S, Lasalvia, A (2009). The contribution of epidemiology to defining the most appropriate approach to genetic research on schizophrenia. Epidemiologia e Psichiatria Sociale 8, 81–90.CrossRefGoogle Scholar
Tosato, S, Ruggeri, M, Bonetto, C, Bertani, M, Marrella, G, Lasalvia, A, Cristofalo, D, Aprili, G, Tansella, M, Dazzan, P, Diforti, M, Murray, RM, Collier, DA (2007). Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. American Journal of Medical Genetic Part B Neuropsychiatric Genetic 144B, 647–659.CrossRefGoogle Scholar
van Os, J, Kapur, S (2009). Schizophrenia. Lancet 374, 635–645.CrossRefGoogle ScholarPubMed
van Wijngaarden, B, Schene, A, Koeter, M, Vázquez-Barquero, JL, Knudsen, HC, Lasalvia, A, McCrone, P, the EPSILON Study Group (2000). Caregiving in schizophrenia: development, internal consistency and reliability of the Involvement Evaluation Questionnaire-European version (IEQ). British Journal of Psychiatry 177 (Suppl. 39), 21–27.CrossRefGoogle Scholar
Weinberger, DR (1995). From neuropathology to neurodevelopment. Lancet 34, 6552–6557.Google Scholar
World Health Organization (1988). Disability Assessment Schedule-II (DAS). World Health Organization: Geneva.Google Scholar
World Health Organization (1992a). Schedules for Clinical Assessment in Neuropsychiatry (SCAN), version 1.0. World Health Organization: Geneva.Google Scholar
World Health Organization (1992b). Life Chart Schedule (LCS). World Health Organization: Geneva.Google Scholar
Wunderink, L, Sytema, S, Nienhuis, FJ, Wiersma, D (2009). Clinical recovery in first-episode psychosis. Schizophrenia Bulletin 35, 362–369.CrossRefGoogle ScholarPubMed