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WRL 105 strain live attenuated influenza vaccine; comparison of one and two dose schedules

Published online by Cambridge University Press:  15 May 2009

A. E. J. Evans ,
E. Letley ,
R. P. Ferris  and
D. S. Freestone
A. E. J. Evans
Affiliation:
Works Medical Officer, I.C.I. Organics Division, Manchester
E. Letley
Affiliation:
The Welicome Research Laboratories, Beckenham, Kent
R. P. Ferris
Affiliation:
The Welicome Research Laboratories, Beckenham, Kent
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Summary

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Haemagglutinating inhibiting antibody (HAI) responses were determined and clinical reactions recorded in 162 adult volunteers who received either 1 or 2 intranasal doses of 107·0 EID 50 WRL 105 strain live influenza vaccine or placebo. After administration of a single dose of vaccine significant antibody responses were obtained in 69 (70%) of 98 volunteers with initial antibody titres of ≤ 1/20. Of the 70 volunteers who received a second dose of vaccine, 62 provided a further post-vaccination sample of serum, and only 3 (4·8 %), who had not responded to the first dose of vaccine, produced a significant antibody response.

Local, upper respiratory and constitutional symptoms were recorded more frequently after the administration of a first dose of vaccine than after placebo or a second dose of vaccine. The symptoms were of a minor nature except in one volunteer who, after the first dose of vaccine, developed influenzal symptoms followed by bronchitis.

Type
Research Article
Information
Journal of Hygiene , Volume 77 , Issue 3 , December 1976 , pp. 327 - 332
Copyright
Copyright © Cambridge University Press 1976

References

REFERENCES

Freestone, D. S., White, W. G., Barnes, G. M., Bowker, C. H., Letley, E., & Ferris, R. D. (1976). A clinical trial of WRL 105 strain live attenuated influenza vaccine comparing four Methods of intrasanal vaccination. Journal of Hygiene 76, 459.CrossRefGoogle ScholarPubMed
Hillary, I. B. (1971). Trials of intranasally athninistered rubella vaccine. Journal of Hygiene 69, 547.Google ScholarPubMed
Moffat, M. A. J., Stealey, V. M., Freestone, D. S., & MacDonald, A. (1976). Assessment of the immunogenicity, reactivity and transmissibility of recombinant WRL 105 strain live attenuated influenza vaccine. Journal of Biological Standardization (in the Press).CrossRefGoogle Scholar
Morris, C. A., Freestone, D. S., Stealey, V. M., & Oliver, P. R. (1975). Recombinant WRL 105 strain live attenuated influenza vaccine. Immunogenicity, reactivity, and transmissibility. Lancet ii, 196.CrossRefGoogle Scholar
Sever, J. L. (1962). Application of a microtechnique to viral serological investigations. Journal of Immunology 88, 320.CrossRefGoogle ScholarPubMed
Stealey, V. M., McCahon, D., & Freestone, D. S. (1975). Preparation and characterisation of live recombinant influenza vaccine. Paper presented at the I.A.B.S. Symposium, Isle of Man, September 1975.Google Scholar
Takatzy, G. (1955). The use of spiral loops in serological and virological micro-methods. Acta microbiologica Academiae scientiarum hungaricae 3, 191.Google Scholar
Zealley, H., Morrison, A. M., & Freestone, D. S. (1974). Dose response studies with Wistar RA 27/3 strain live attenuated rubella vaccine. Journal of Biological Standardization 2, 111.CrossRefGoogle ScholarPubMed