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Vaccination against Hong Kong influenza in Britain, 1968–9: A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines*

Published online by Cambridge University Press:  15 May 2009

D. A. J. Tyrrell ,
Rosemary Buckland ,
D. Rubenstein  and
D. M. Sharpe
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
Rosemary Buckland
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
D. Rubenstein
Affiliation:
Clinical Research Centre Laboratories, National Institute for Medical Research, The Ridgeway, London, N. W. 7
D. M. Sharpe
Affiliation:
Medical Research Council, 20 Park Crescent, London, WIN 4AL
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Summary

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Studies of the effect of Hong Kong (HK) influenza vaccine were made in adults and children in Great Britain during 1968 and 1969. The vaccines were administered intramuscularly and also by intranasal spray. The serum antibody response was studied in 284 subjects. Most developed rising titres to vaccine given intramuscularly and few to vaccine given intranasally. Deoxycholate-split vaccine was as potent as conventional whole virus vaccine. Antibody titres were maintained for months. Over 4000 subjects in factories, offices and schools were observed during the epidemic. The incidence of disease was not significantly reduced by either form of vaccination. A survey was made of epidemics in boarding schools in which some of the pupils had been vaccinated, in six with commercial polyvalent vaccine and in five with HK; there was a lower incidence of influenza in two schools vaccinated 2 or 4 weeks earlier with HK vaccine.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 3 , September 1970 , pp. 359 - 368
Copyright
Copyright © Cambridge University Press 1970

References

REFERENCES

Beare, A. S. (1970). Laboratory characteristics of attenuated influenza viruses. Bulletin of the World Health Organization 41, 595.Google Scholar
Beare, A. S., Tyrrell, D. A. J., Hobson, D., Howells, C. H. L., Pereira, M. S., Pollock, T. M. & Tyler, L. E. (1969). Live influenza B vaccine in volunteers: a report to the Medical Research Council by their Committee on Influenza and other Respiratory Virus Vaccines. Journal of Hygiene 67, 1.CrossRefGoogle Scholar
Committee on Influenza and Other Respiratory Virus Vaccines (1958). Trials of an Asian influenza vaccine. British Medical Journal i, 415.Google Scholar
Hobson, D. (1967). Immunization against respiratory virus infections. In Modern Trends in Immunology, 2, 53. Eds Cruickshank, R. and Weir, D. M.. London: Butterworths.Google Scholar
Hobson, D., Baker, F. A., Chivers, C. P., Reed, S. E. & Sharp, D. (1970). A comparison of monovalent Hong Kong influenza virus vaccine with vaccines containing only pre-1968 Asian strains in adult volunteers. Journal of Hygiene 68, 369–378.CrossRefGoogle ScholarPubMed
Laver, W. G. (1961). Purification, N-terminal amino acid analysis and disruption of an influenza virus. Virology 14, 499.CrossRefGoogle ScholarPubMed
Ogra, P. L. & Karzon, D. T. (1969). Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine. Journal of Immunology 102, 1423.CrossRefGoogle ScholarPubMed
Waldman, R. H., Mann, J. J. & Small, P. A. Jr. (1969). Immunization against influenza. Prevention of illness in man by aerosolized inactivated vaccine. Journal of the American Medical Association 207, 520.CrossRefGoogle Scholar