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Tuberculous morbidity in Swiss albino mice immunized with BCG*

Published online by Cambridge University Press:  15 May 2009

Richard Costello  and
Sara C. Slats
Richard Costello
Affiliation:
The Rockefeller University, New York, New York10021
Sara C. Slats
Affiliation:
The Rockefeller University, New York, New York10021
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Summary

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Study was made of the effect of BCG vaccination on the establishment of experimental tuberculous infection in mice. To this end, mice were infected with small quantities of virulent human bacilli administered by the respiratory route. The quantity of bacilli present for inhalation was so controlled as to permit only a finite percentage of unvaccinated animals to become infected. The relative proportion of mice infected by inhaling these small numbers of virulent bacilli was not found to be lowered by prior BCG vaccination. Thus, pulmonary tissue of immunized mice was not able to prevent the initial lodgement of virulent tubercle bacilli. The growth of virulent organisms in infected lungs, however, was significantly retarded by prior vaccination.

Type
Research Article
Information
Journal of Hygiene , Volume 68 , Issue 4 , December 1970 , pp. 589 - 599
Copyright
Copyright © Cambridge University Press 1970

References

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