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Tuberculosis is still a major cause of cervical lymphadenopathies in adults from developing countries

Published online by Cambridge University Press:  23 December 2003

A. HERNÁNDEZ-SOLÍS ,
R. CICERO-SABIDO ,
H. OLIVERA ,
V. RIVERO ,
E. RAMÍREZ  and
A. ESCOBAR-GUTIÉRREZ
A. HERNÁNDEZ-SOLÍS
Affiliation:
Unidad de Neumología, Hospital General de México and Facultad de Medicina, UNAM, México
R. CICERO-SABIDO
Affiliation:
Unidad de Neumología, Hospital General de México and Facultad de Medicina, UNAM, México
H. OLIVERA
Affiliation:
Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México
V. RIVERO
Affiliation:
Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México
E. RAMÍREZ
Affiliation:
Unidad de Neumología, Hospital General de México and Facultad de Medicina, UNAM, México
A. ESCOBAR-GUTIÉRREZ
Affiliation:
Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México
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Abstract

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To establish the frequency of infectious aetiology in Mexican adult patients with cervical lymphadenopathies (CLAs), 87 consecutive patients with enlarged cervical lymphatic nodes, HIV negative and without anti-tuberculous treatment, were selected from a tertiary-level speciality concentration hospital. Histopathological studies, investigation of acid-fast bacilli, cultures in Löwenstein–Jensen and Mycobacterium growth indicator tube (MGIT) media, and in-house polymerase chain reaction (PCR) with IS6110-based primers for Mycobacterium tuberculosis complex were performed in resected lymphatic nodes. Non-infectious aetiology corresponded to 45 cases (52%). Tuberculosis was suspected in 42 cases (48%) by histology and confirmed positive results were obtained by staining in 8 (19%), by culture in 23 (55%), and by PCR in 34 (81%) patients. All were confirmed after therapeutic success. In addition to the epidemiological transition process occurring in Mexico, tuberculosis remains an important cause of CLA. Histopathology with confirmatory studies including PCR can detect tuberculous aetiology.

Type
Research Article
Information
Epidemiology & Infection , Volume 131 , Issue 3 , December 2003 , pp. 1071 - 1076
Copyright
2003 Cambridge University Press